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首页> 美国卫生研究院文献>Journal of Clinical Medicine Research >Focal Epithelial Hyperplasia (Heck’s Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review
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Focal Epithelial Hyperplasia (Heck’s Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review

机译：一名57岁巴西患者的局灶性上皮增生（Heck病）：病例报告和文献复习

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摘要

Focal epithelial hyperplasia (FEH), or Heck’s disease, is a rare disease of the oral mucosa associated with infection by some subtypes of human papilloma virus, especially subtypes 13 or 32. The disease is predominantly found in children and adolescents with indigenous heritage, but other ethnic groups can be affected worldwide. To the best of the authors’ knowledge, it has not been reported in Brazil’s elderly population. This article describes a case of FEH in a 57-year-old Brazilian patient presenting since childhood, with multiple lesions in the lips, buccal mucosa and tongue. The solitary tongue lesion underwent excisional biopsy and the histopathological analysis showed parakeratosis, acanthosis, rete pegs with a club-shaped appearance, koilocytosis and the presence of mitosoid cells. These microscopic findings in conjunction with clinical presentation were sufficient to establish the accurate diagnosis of FEH. Polymerase chain reaction (PCR) was performed, but no one human papillomavirus (HPV) subtype could be identified. Clinicians must be aware of this rare oral disease, which can even affect elderly patients, as we described here. Treatment may be indicated in selected cases due to esthetic and/or functional problems.
机译：局灶性上皮增生（FEH）或Heck病是一种罕见的口腔粘膜疾病，与人类乳头瘤病毒的某些亚型（尤其是13或32型）的感染有关。其他种族也可能在世界范围内受到影响。据作者所知，巴西的老年人口尚未报道。本文介绍了一名57岁的巴西儿童，从儿童期开始就出现FEH的病例，嘴唇，颊粘膜和舌头有多处病变。对孤立的舌部病变进行切除活检，组织病理学分析显示角化不全，棘皮症，网状柄状网状钉，白细胞增多和有丝分裂样细胞的存在。这些微观发现结合临床表现足以确定FEH的准确诊断。进行了聚合酶链反应（PCR），但未鉴定出一种人乳头瘤病毒（HPV）亚型。如我们在此所述，临床医生必须意识到这种罕见的口腔疾病，它甚至可能影响老年患者。在某些情况下，由于美学和/或功能问题可能需要治疗。

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