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首页> 美国卫生研究院文献>Nanomaterials >Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy
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Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy

机译：炎症性肠病：生活方式和纳米医生新趋势的出现作为药物治疗的现代工具

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摘要

The human intestine, which harbors trillions of symbiotic microorganisms, may enter into dysbiosis when exposed to a genetic defect or environmental stress. The naissance of chronic inflammation due to the battle of the immune system with the trespassing gut bacteria leads to the rise of inflammatory bowel disease (IBD). Though the genes behind the scenes and their link to the disease are still unclear, the onset of IBD occurs in young adults and has expanded from the Western world into the newly industrialized countries. Conventional drug deliveries depend on a daily heavy dosage of immune suppressants or anti-inflammatory drugs targeted for the treatment of two types of IBD, ulcerative colitis (UC) and Crohn’s disease (CD), which are often associated with systemic side effects and adverse toxicities. Advances in oral delivery through nanotechnology seek remedies to overcome the drawbacks of these conventional drug delivery systems through improved drug encapsulation and targeted delivery. In this review, we discuss the association of genetic factors, the immune system, the gut microbiome, and environmental factors like diet in the pathogenesis of IBD. We also review the various physiological concerns required for oral delivery to the gastrointestinal tract (GIT) and new strategies in nanotechnology-derived, colon-targeting drug delivery systems.
机译：在暴露于遗传缺陷或环境应激时，人类肠道，其中八氧化氮素的共生微生物，可能进入困难。由于免疫系统的战斗与侵入肠道细菌导致的慢性炎症的苛刻症导致炎症性肠病（IBD）的兴起。虽然场景背后的基因及其与疾病的联系仍然尚不清楚，但IBD的发病发生在年轻人身上，并从西方世界扩展到新工业化国家。常规药物递送依赖于每日重重剂量的免疫抑制剂或抗炎药，旨在治疗两种IBD，溃疡性结肠炎（UC）和CROHN疾病（CD），其通常与系统性副作用和不良毒性有关。通过纳米技术通过纳米技术进行口头递送的进展，通过改善药物包封和靶向递送来克服这些常规药物递送系统的缺点。在本综述中，我们讨论了IBD发病机制中遗传因素，免疫系统，肠道微生物组和环境因素的协会。我们还审查了口服递送到胃肠道（GIT）和纳米技术衍生的结肠靶向药物递送系统的新策略所需的各种生理担忧。

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