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首页> 美国卫生研究院文献>Molecules >Phytochemical and Biological Evaluation of a Newly Designed Nutraceutical Self-Nanoemulsifying Self-Nanosuspension for Protection and Treatment of Cisplatin Induced Testicular Toxicity in Male Rats
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Phytochemical and Biological Evaluation of a Newly Designed Nutraceutical Self-Nanoemulsifying Self-Nanosuspension for Protection and Treatment of Cisplatin Induced Testicular Toxicity in Male Rats

机译：一种新设计的营养素自纳乳化自纳米术治疗和治疗顺铂诱导雄性大鼠睾丸毒性的植物化学和生物学评价

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The incorporation of cisplatin (CP) as a cytotoxic antineoplastic agent in most chemotherapeutic protocols is a challenge due to its toxic effect on testicular tissues. Natural compounds present a promising trend in research, so a new nutraceutical formulation (NCF) was designed to diminish CP spermatotoxicity. A combination of three nutraceutical materials, 250 mg Spirulina platensis powder (SP), 25 mg Tribulus terrestris L. extract (TT), and 100 mg fish oil (FO) were formulated in self-nanoemulsifying self-nanosuspension (SNESNS). SP was loaded into the optimized self-nanoemulsifying system (30% FO, 50% span 80/cremophor EL and 20% isopropanol) and mixed with TT aqueous solution to form SNESNS. For the SP, phytochemical profiling revealed the presence of valuable amounts of fatty acids (FAs), amino acids, flavonoids, polyphenols, vitamins, and minerals. Transmission electron microscopy (TEM) and particle size analysis confirmed the formation of nanoemulsion-based nanosuspension upon dilution. Method validation of the phytochemical constituents in NCF has been developed. Furthermore, NCF was biologically evaluated on male Wistar rats and revealed the improvement of spermatozoa, histopathological features, and biochemical markers over the CP and each ingredient group. Our findings suggest the potential of NCF with SNESNS as a delivery system against CP-induced testicular toxicity in male rats.
机译：在大多数化学治疗方案中作为细胞毒性抗肿瘤剂的顺铂（CP）的掺入是由于其对睾丸组织的毒性作用导致的挑战。天然化合物呈现了一种有前途的研究趋势，因此设计了一种新的营养制剂（NCF）旨在削弱CP精子毒性。三种营养素材料，250mg螺旋藻粉末（SP），25mg Tribulus Terrestris L.提取物（TT）和100mg鱼油（FO）的组合在自纳中乳化自纳米液（Snesns）中配制。将SP加载到优化的自纳乳液系统（30％FO，50％跨度80 / Cremophor EL和20％异丙醇）中，并与TT水溶液混合以形成鼻涕。对于SP，植物化学分析揭示了有价值量的脂肪酸（Fas），氨基酸，黄酮类化合物，多酚，维生素和矿物质的存在。透射电子显微镜（TEM）和粒度分析证实在稀释时形成了纳米乳液的纳米柱悬浮液。已经开发了NCF中植物化学成分的方法验证。此外，NCF在雄性Wistar大鼠上生物学评价，并揭示了在CP和每种成分组上的精子，组织病理学特征和生物化学标记的改善。我们的研究结果表明NCF与Snesns作为雄性大鼠CP诱导睾丸毒性的递送系统的潜力。

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