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首页> 美国卫生研究院文献>Pharmacy: Journal of Pharmacy Education and Practice >Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation
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Implementation of a Pharmacogenomic Testing Service through Community Pharmacy in the Netherlands: Results from an Early Service Evaluation

机译：通过荷兰的社区药房实施药物替代测试服务：早期服务评估的结果

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摘要

Community pharmacy services have evolved to include medical and pharmaceutical interventions alongside dispensing. While established pharmacogenomic (PGx) testing is available throughout the Netherlands, this is primarily based in hospital environments and for specialist medicines. The aim of this work was to describe how best to implement PGx services within community pharmacy, considering potential barriers and enablers to service delivery and how to address them. The service was implemented across a selection of community pharmacies in the Netherlands. Data were captured on test outcomes and through a pharmacist survey. Following testing, 17.8% of the clinical samples were recommended to avoid certain medication (based on their current medicines use), and 14.0% to have their dose adjusted. Pre-emptive analysis of genotyped patients showed that the majority (99.2%) had actionable variants. Pharmacists felt confident in their operational knowledge to deliver the service, but less so in applying that knowledge. Delivering the service was believed to improve relationships with other healthcare professionals. These results add to the evidence in understanding how PGx can be delivered effectively within the community pharmacy environment. Training pharmacists in how to respond to patient queries and make clinical recommendations may enhance service provision further.
机译：社区药房服务进化了，包括分配的医疗和药品干预措施。虽然在荷兰提供了已建立的药物替代物（PGX）测试，但这主要是位于医院环境和专家药物。这项工作的目的是描述如何最好地在社区药房内实施PGX服务，考虑潜在的障碍和使能力交付以及如何解决它们。该服务是在荷兰的各种社区药典中实施。数据被捕获在测试结果和药剂师调查中。在测试之后，建议使用17.8％的临床样品来避免某些药物（根据他们目前的药物使用），14.0％的剂量调节。基因分型患者的先发制人分析表明，大多数（99.2％）具有可行的变异。药剂师对他们的操作知识感到充满信心，以提供服务，但在申请知识方面较少。据信，提供服务，以改善与其他医疗保健专业人员的关系。这些结果为了解PGX如何在社区药房环境中有效地提供的证据。培训药剂师如何应对患者查询，并使临床建议进一步提高服务拨备。

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