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Improving Successful Introduction after a Negative Food Challenge Test: How to Achieve the Best Result?

机译：在负面食物挑战后提高成功介绍：如何实现最佳结果？

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摘要

Oral food challenges (OFC) confirm or exclude the presence of a food allergy. The outcome can be positive (allergic symptoms), inconclusive, or negative (no symptoms). In the case of a negative OFC, parents and children are advised to introduce the challenged food allergen into their diet. However, previous studies showed difficulties in a successful introduction at home. The aim of this prospective non-randomized intervention study is to evaluate the effect of a new strategy with more guidance regarding the dietary introduction after a negative food challenge test. We compared two cohorts: an historical (retrospective) control group of 157 children, previously described, who did not receive any special advice after a negative OFC, versus a new cohort consisting of 104 children, who were guided according to our new strategy of written introduction schemes, food diaries, and several phone calls. In the historical control group, introduction was successful in 56%, partially successful in 16%, and 28% failed to introduce at home. After introduction of our new strategy, complete introduction was found in 82%, 11% had partially introduced, and only 8% failed to introduce the allergen. In conclusion, comprehensive advice and dietary recommendation after a negative OFC results in an increase in successful home introduction. Therefore, more attention, guidance, and follow-up of children and parents are desirable after a negative OFC.
机译：口腔食物挑战（OFC）证实或排除了食物过敏的存在。结果可以是阳性（过敏症状），不确定的或阴性（无症状）。在负面的案例中，建议父母和孩子们将挑战性食物过敏原介绍给他们的饮食。然而，之前的研究表明在家里成功介绍的困难。本潜在非随机干预研究的目的是评估新战略对膳食挑战试验后膳食引入的更多指导的影响。我们比较了两个队列：157名儿童的历史（回顾性）对照组，此前没有收到任何特殊建议，在负面的消极之后，与由104名儿童组成的新队列，他们是根据我们所写的新战略指导的介绍计划，食物日记和几个电话。在历史对照组中，介绍成功于56％，部分成功16％，28％未能在家里引入。在引入我们的新策略后，在82％中发现了完整的介绍，11％部分介绍，只有8％未能介绍过敏原。总之，在负面的负面介绍中导致综合建议和膳食推荐导致成功的家庭介绍。因此，在负面的消极后，儿童和父母的更多关注，指导和随访是可取的。

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