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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Surface Modification of Electrospun Scaffolds for Endothelialization of Tissue-Engineered Vascular Grafts Using Human Cord Blood-Derived Endothelial Cells
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Surface Modification of Electrospun Scaffolds for Endothelialization of Tissue-Engineered Vascular Grafts Using Human Cord Blood-Derived Endothelial Cells

机译：使用人体脐带血来源的内皮细胞对组织工程血管移植物进行内皮化的电纺支架的表面修饰

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Tissue engineering has gained attention as an alternative approach for developing small diameter tissue-engineered vascular grafts intended for bypass surgery, as an option to treat coronary heart disease. To promote the formation of a healthy endothelial cell monolayer in the lumen of the graft, polycaprolactone/gelatin/fibrinogen scaffolds were developed, and the surface was modified using thermoforming and coating with collagen IV and fibronectin. Human cord blood-derived endothelial cells (hCB-ECs) were seeded onto the scaffolds and the important characteristics of a healthy endothelial cell layer were evaluated under static conditions using human umbilical vein endothelial cells as a control. We found that polycaprolactone/gelatin/fibrinogen scaffolds that were thermoformed and coated are the most suitable for endothelial cell growth. hCB-ECs can proliferate, produce endothelial nitric oxide synthase, respond to interleukin 1 beta, and reduce platelet deposition.
机译：组织工程作为开发用于旁路手术的小直径组织工程血管移植物的替代方法而受到关注，作为治疗冠心病的一种选择。为了促进在移植物内腔中形成健康的内皮细胞单层，开发了聚己内酯/明胶/纤维蛋白原支架，并通过热成型对表面进行了修饰，并用胶原蛋白IV和纤连蛋白包被。将人脐血来源的内皮细胞（hCB-ECs）接种到支架上，并在静态条件下使用人脐静脉内皮细胞作为对照评估健康内皮细胞层的重要特征。我们发现，热成型和涂覆的聚己内酯/明胶/纤维蛋白原支架最适合内皮细胞生长。 hCB-ECs可以增殖，产生内皮型一氧化氮合酶，对白介素1β产生反应，并减少血小板沉积。

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