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Timeline of Translational Formulation Technologies for Cancer Therapy: Successes Failures and Lessons Learned Therefrom

机译：癌症治疗的翻译制剂技术时间表：从中吸取的成功失败和经验教训

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Over the past few decades, the field of cancer therapy has seen a significant change in the way in which formulations are designed and developed, resulting in more efficient products that allow us to ultimately achieve improved drug bioavailability, efficacy, and safety. However, although many formulations have entered the market, many others have fallen by the wayside leaving the scientific community with several lessons to learn. The successes (and failures) achieved with formulations that have been approved in Europe and/or by the FDA for the three major types of cancer therapy (peptide-based therapy, chemotherapy, and radiotherapy) are reviewed herein, covering the period from the approval of the first prolonged-release system for hormonal therapy to the appearance of the first biodegradable microspheres intended for chemoembolization in 2020. In addition, those products that have entered phase III clinical trials that have been active over the last five years are summarized in order to outline future research trends and possibilities that lie ahead to develop clinically translatable formulations for cancer treatment.
机译：在过去的几十年里，癌症治疗领域已经看到了制剂的设计和开发的方式发生了重大变化，导致更有效的产品，使我们能够最终实现改善的药物生物利用度，功效和安全性。然而，虽然许多配方进入市场，但许多其他商品落后于那些与科学界有几课学习。在此批准的欧洲和/或FDA批准的配方实现的成功（和失败）在此处审查了核准的三种主要类型的癌症治疗（肽类治疗，化疗和放射疗法），涵盖了批准的期限对荷尔蒙治疗的第一个延长释放系统，以在2020年进行化学栓塞的第一个可生物降解的微球的外观。此外，已经总结了在过去五年中有活跃的第III期临床试验的产品总结了概述未来的研究趋势和可能性，在发育癌症治疗的临床上可翻译配方。

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