• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Pharmaceutics >Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis
【2h】

Clinical Efficacy of Single Application Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review and Network Meta-Analysis

机译：单一应用局部药物递送和辅助剂在非牙科牙周治疗中的临床疗效：系统审查与网络荟萃分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This review aimed to rank the clinical efficacy of commercially available single-application local drug delivery and adjunctive agents (LDAs) compared with subgingival mechanical debridement (SMD) in nonsurgical periodontal therapy (NSPT). Randomized controlled clinical trials that compared LDAs against SMD alone or with placebo in adults (aged at least 18 years) diagnosed with periodontitis with a minimum of 6 months follow-up were included. A frequentist approach to random-effects network meta-analysis was implemented. The efficacies of the LDAs measured by probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain were reported as mean difference (MD) with 95% confidence intervals (CIs). The treatments were ranked according to their P-score. Four network meta-analyses suggested that sulfonic/sulfuric acid gel (PPD MD −1.13 mm, 95% CI −1.74 to −0.53, P-score 0.91; CAL MD −1.09 mm, 95% CI −1.58 to −0.61, P-score 0.95) and doxycycline hyclate gel (PPD MD −0.90 mm, 95% CI −1.50 to −0.30, P-score 0.93; CAL MD −0.84 mm, 95% CI −1.40 to −0.28, P-score 0.92) were the most effective in reducing PPD and gaining CAL in split-mouth and parallel studies, respectively (moderate certainty of evidence). LDAs have differing efficacies, but they present with possible clinical significance over SMD alone in NSPT.
机译：该审查旨在将商业上可获得的单申请局部药物递送和辅助剂（LDA）的临床疗效排列与非牙科牙周治疗（NSPT）中的龈下机械清新（SMD）进行临床疗效。随机对照的临床试验，将LDA与SMD单独或与成人（年龄至少18岁）的安慰剂进行诊断为期6个月的后续行动。实施了频繁的随机效应网络元分析方法。通过探测口袋深度（PPD）降低和临床附着水平（CAL）增益测量的LDA的效果被报告为平均差异（MD），置信间隔95％（CIS）。根据其P级评分排名。四个网络元分析表明，磺酸/硫酸凝胶（PPD MD -1.13mm，95％CI -1.74至-0.53，P级0.91; CAL MD -1.09 mm，95％CI -1.58至-0.61，P-得分0.95）和强霉素杂环凝胶（PPD MD -0.90 mm，95％CI -1.50至-0.30，P级0.93; CAL MD -0.84 mm，95％CI -1.40至-0.28，P-Score 0.92）是最有效地减少PPD和在分裂口和平行研究中的CAL（中等肯定的证据）。 LDA有不同的效率，但它们在NSPT中展示了SMD的可能临床意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号