• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Pharmaceutics >Relating Advanced Electrospun Fiber Architectures to the Temporal Release of Active Agents to Meet the Needs of Next-Generation Intravaginal Delivery Applications
【2h】

Relating Advanced Electrospun Fiber Architectures to the Temporal Release of Active Agents to Meet the Needs of Next-Generation Intravaginal Delivery Applications

机译：将高级电纺纤维架构与活性剂的临时释放相关联以满足下一代阴道内递送应用的需求

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Electrospun fibers have emerged as a relatively new delivery platform to improve active agent retention and delivery for intravaginal applications. While uniaxial fibers have been explored in a variety of applications including intravaginal delivery, the consideration of more advanced fiber architectures may offer new options to improve delivery to the female reproductive tract. In this review, we summarize the advancements of electrospun coaxial, multilayered, and nanoparticle-fiber architectures utilized in other applications and discuss how different material combinations within these architectures provide varied durations of release, here categorized as either transient (within 24 h), short-term (24 h to one week), or sustained (beyond one week). We seek to systematically relate material type and fiber architecture to active agent release kinetics. Last, we explore how lessons derived from these architectures may be applied to address the needs of future intravaginal delivery platforms for a given prophylactic or therapeutic application. The overall goal of this review is to provide a summary of different fiber architectures that have been useful for active agent delivery and to provide guidelines for the development of new formulations that exhibit release kinetics relevant to the time frames and the diversity of active agents needed in next-generation multipurpose applications.
机译：电纺纤维已经作为相对较新的递送平台出现，以改善阴道内应用中活性剂的保留和递送。尽管已经在包括阴道内递送在内的各种应用中研究了单轴纤维，但是考虑采用更先进的纤维结构可能会提供新的选择，以改善对女性生殖道的递送。在这篇综述中，我们总结了电纺同轴，多层和纳米颗粒纤维体系结构在其他应用中的应用进展，并讨论了这些体系结构中的不同材料组合如何提供不同的释放持续时间，此处分为瞬态（24小时内），短时-长期（24小时至1周）或持续（超过1周）。我们寻求系统地将材料类型和纤维结构与活性剂释放动力学联系起来。最后，我们探索如何将从这些体系结构中汲取的教训应用于满足特定预防性或治疗性应用的未来阴道内递送平台的需求。这篇综述的总体目标是概述可用于活性剂递送的不同纤维结构，并为开发新制剂提供指导，这些制剂表现出与时间框架和活性剂所需多样性有关的释放动力学。下一代多功能应用程序。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号