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Therapeutic concentration achievement and allograft survival comparing usage of conventional tacrolimus doses and CYP3A5 genotype‐guided doses in renal transplantation patients

机译：治疗浓度成果和同种异体移植的存活率比较使用常规的巨杆菌剂量和CYP3A5基因型引导剂量在肾移植患者中的用量

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摘要

Although cytochromeP450(CYP)3A5 gene polymorphism affects personalized tacrolimus doses, there is no consensus as to whether CYP3A5 genotypes should be determined to adjust the doses. The aims were to compare the therapeutic ranges and clinical outcomes between the conventional and genotype‐guided tacrolimus doses.

机译：虽然Cytochromep450（CYP）3A5基因多态性影响个性化的Tacolimus剂量，但对于Cyp3A5基因型是否应确定是否应确定调节剂量。目的是比较常规和基因型引导的Tacrolimus剂量之间的治疗范围和临床结果。

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期刊名称 British Journal of Clinical Pharmacology
作者
Sirirat Anutrakulchai; Cholatip Pongskul; Kittrawee Kritmetapak; Chulaporn Limwattananon; Suda Vannaprasaht;
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作者单位

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年(卷),期 2019(85),9
年度 2019
页码 1964–1973
总页数 10
原文格式 PDF
正文语种
中图分类药学;
关键词

机译：CYP3A5;延迟移植函数;稳态;Tacrolimus;治疗范围;

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专利

1. Therapeutic concentration achievement and allograft survival comparing usage of conventional tacrolimus doses and CYP3A5 CYP3A5 genotype‐guided doses in renal transplantation patients [J] . Anutrakulchai Sirirat, Pongskul Cholatip, Kritmetapak Kittrawee, British Journal of Clinical Pharmacology . 2019,第9期

机译：治疗浓度成果和同种异体移植存活率比较使用常规的巨蟹蛋白剂量和CYP3A5 CYP3A5基因型引导剂量在肾移植患者中的用量
2. Impact of the CYP3A5 genotype on the distributions of dose-adjusted trough concentrations and incidence of rejection in Japanese renal transplant recipients receiving different tacrolimus formulations [J] . Takenori Niioka, Hideaki Kagaya, Mitsuru Saito, Clinical and experimental nephrology . 2017,第5期

机译：CYP3A5基因型对日本肾移植受者的剂量调整槽浓度分布及抑制率的影响，接受不同的立咯患者制剂
3. CYP3A5 genotyping may reduce the cost of care and guide dosing in paediatric renal transplant recipients treated with tacrolimus [J] . Stephen M. Roper, Mini Michael, Eileen D. Brewer, Australasian Medical Journal . 2017,第5期

机译：CYP3A5基因分型可降低接受他克莫司治疗的小儿肾移植受者的护理费用并指导剂量
4. Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients [C] . NIE Xin-min, GUI Rong, ZHAO Hong-shan, Postdoctoral Symposium for Celebration of 20th Anniversary of the Foundation of Chinese Postdoctoral System; 2005; . 2005

机译：CYP3A5基因多态性对肾移植患者他克莫司血药浓度的影响
5. Correction: Tacrolimus dose requirement based on the CYP3A5 genotype in renal transplant patients [O] . Lihui Qu, Yingying Lu, Meike Ying, 2020

机译：校正：肾移植患者基于CYP3A5基因型的他克莫司剂量需求
6. Therapeutic concentration achievement and allograft survival comparing usage of conventional tacrolimus doses and CYP3A5 genotype‐guided doses in renal transplantation patients [O] . Sirirat Anutrakulchai, Cholatip Pongskul, Kittrawee Kritmetapak, 2019

机译：治疗浓度成果和同种异体移植的存活率比较使用常规的巨杆菌剂量和CYP3A5基因型引导剂量在肾移植患者中的用量

Therapeutic concentration achievement and allograft survival comparing usage of conventional tacrolimus doses and CYP3A5 genotype‐guided doses in renal transplantation patients

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