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首页> 美国卫生研究院文献>Journal of Animal Science >286 Effects of dietary peroxidized lipids and antioxidant supplementation in the drinking water on growth oxidative and immune status of newly weaned piglets
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286 Effects of dietary peroxidized lipids and antioxidant supplementation in the drinking water on growth oxidative and immune status of newly weaned piglets

机译：286膳食过氧化脂质和抗氧化剂补充在新断奶仔猪生长氧化和免疫状态下的饮用脂质和抗氧化剂的影响

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The objective of the present study was to evaluate the use of vitamin E (VitE) and phytogenic compounds (PHYTO) in drinking water on performance, oxidative stress, and immune status of weaned piglets fed peroxidized lipids. In a 35-day study, 21-d old weaned piglets (n = 96; 6.10±0.64 kg BW) were assigned within sex and BW blocks to 1 of 4 dietary treatments, using 24 pens (4 pigs/pen; 6 replications/treatment). Diets contained either 6% human-grade soybean oil or 6% soybean oil which was peroxidized for 12 d at 80°C with constant air flow at 50 L/min (initial peroxide value, anisidine value, hexanal, and 2,4-decadienal concentrations were 4.1 vs. 141.6 meq/kg, 1.7 vs. 106, < 5 vs. 99 mg/kg, and 8 vs. 720 mg/kg for control and peroxidized oil, respectively). Pigs fed peroxidized lipids received drinking water without (control) or with supplemental VitE (100 IU/L d-α-tocopherol) or PHYTO (60 µL/L from d 1–7; 30 µL/L from d 8–35). Pigs fed control diet received control water only. Overall, peroxidized lipids decreased (P < 0.001) BW (18.20 vs. 21.55 kg) and ADG (347 vs. 441 g/day), and tended to decrease ADFI (P = 0.14; 537 vs. 617 g/day) and G:F (P = 0.07; 645 vs. 715 g/kg). Peroxidation decreased serum vitamin E (P = 0.03) which could be restored (P = 0.01) by VitE in the water, but not PHYTO. Serum concentrations of interferon-γ, interleukin(IL)-1α, IL-1β, IL-1ra, IL2, IL4, IL-6, IL10, IL-12, IL-18, TNF-α, malondialdehyde, protein carbonyl, and total antioxidant capacity were not impacted by treatments (P > 0.05). Serum 8-hydroxydeoxyguanosine was reduced (P = 0.001) with feeding peroxidized lipids and this was not altered by supplemental antioxidants (P = 0.45). Peroxidized lipids clearly reduced growth performance, which did not appear to be related to oxidative stress markers or immune-regulatory cytokines. The negative effects of peroxidized lipids could not be improved by vitamin E or PHYTO supplemented in drinking water.
机译：本研究的目的是评估维生素E（vite）和植物生成化合物（Phyto）在饮用水中饮用水，氧化胁迫和供给过氧化脂质的断奶仔猪的免疫状态。在35天的研究中，使用24笔（4只猪/笔; 6次复制/）在性别和BW块中分配21-D旧断奶仔猪（n = 96; 6.10±0.64千克BW）。（4只猪/笔; 6次复制/治疗）。饮食含有6％的人级大豆油或6％大豆油，其在80℃下过氧化12d，在50L / min的恒定空气流（初始过氧化物值，氨酰胺值，己醛和2,4- Decadienal浓度为4.1与141.6meq / kg，1.7 vs.106，<5 vs.99mg / kg，分别用于对照和过氧化油的8克和720mg / kg。饲料过氧化脂质的猪在没有（对照）或用补充vite（100IU / L D-α-生育酚）或PHYTO（来自D 1-7的60μl/ L的含量）或来自D 8-35的30μl/ L的饮用水。猪喂养控制饮食仅接受控制水。总体而言，过氧化脂质降低（P <0.001）BW（18.20 vs.21.55kg）和ADG（347 vs.41克/天），倾向于降低ADFI（P = 0.14; 537与617克/天）和g ：F（p = 0.07; 645与715 g / kg）。过氧化降低血清维生素E（p = 0.03），其可以通过尺寸在水中恢复（p = 0.01），但不是phyto。干扰素-γ，白细胞介素（IL）-1α，IL-1β，IL-1RA，IL2，IL4，IL-6，IL10，IL-12，IL-18，TNF-α，丙二醛，蛋白质羰基和蛋白质羰基和血清浓度总抗氧化能力不会受到处理（P> 0.05）的影响。血清8-羟基氧基胍（P = 0.001）减少（P = 0.001），喂食过氧化脂质，这不会通过补充抗氧化剂（P = 0.45）改变。过氧化的脂质显然降低了生长性能，这似乎与氧化应激标记物或免疫调节细胞因子有关。通过维生素E或Phyto补充在饮用水中不能改善过氧化脂质的负面影响。

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