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首页> 美国卫生研究院文献>Journal of Inflammation Research >Targeting Chemokines and Chemokine Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
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Targeting Chemokines and Chemokine Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

机译：在多发性硬化症和实验性自身免疫脑脊髓炎中靶向趋化因子和趋化因子受体

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摘要

Multiple sclerosis (MS) is an immune-mediated and neurodegenerative disorder that results in inflammation and demyelination of the central nervous system (CNS). MS symptoms include walking difficulties, visual weakening, as well as learning and memory impairment, thus affecting the quality of the patient’s life. Chemokines and chemokine receptors are expressed on the immune cells as well as the CNS resident cells. Several sets of chemokine receptors and their ligands tend to be pathogenic players in MS, including CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL17, CCL19, CCL21, CCL22, CXCL1, CXCL8, CXCL9, CXCL10, CXCL11, and CXCL16. Furthermore, current modulatory drugs that are used in the treatment of MS and its animal model, the experimental autoimmune encephalomyelitis (EAE), affect the expression of several chemokine and chemokine receptors. In this review, we highlight the pathogenic roles of chemokines and their receptors as well as utilizing them as potential therapeutic targets through selective agents, such as specific antibodies and receptor blockers, or indirectly through MS or EAE immunomodulatory drugs.
机译：多发性硬化症（MS）是一种免疫介导的和神经变性疾病，导致中枢神经系统（CNS）的炎症和脱髓鞘。 MS症状包括步行困难，视觉弱化，以及学习和记忆障碍，从而影响患者生命的质量。趋化因子和趋化因子受体在免疫细胞以及CNS驻留细胞上表达。几组趋化因子受体及其配体倾向于是MS中的致病球员，包括CCl2，CCl3，CCl4，CCl5，CCl7，CCl8，CCl11，CCl17，CCl19，CCL21，CCL22，CXCL1，CXCL8，CXCL9，CXCL10，CXCL11和cxcl16。此外，用于治疗MS及其动物模型的目前的调节药物，实验性自身免疫性脑脊髓炎（EAE），影响了几种趋化因子和趋化因子受体的表达。在本综述中，我们突出了趋化因子及其受体的致病作用，以及利用它们作为潜在的治疗靶通过选择性药剂，例如特异性抗体和受体阻滞剂，或间接通过MS或EAE免疫调节药物。

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