首页>
美国卫生研究院文献>Neuropsychopharmacology
>Effect of the dopamine stabilizer (-)-OSU6162 on potentiated incubation of opioid craving after electric barrier-induced voluntary abstinence
【2h】
Effect of the dopamine stabilizer (-)-OSU6162 on potentiated incubation of opioid craving after electric barrier-induced voluntary abstinence
a Timeline of Exp. 1. b Oxycodone self-administration training: Number of oxycodone infusions (0.1 mg/kg/infusion) and inactive and active lever presses during the 6-h sessions. c Electric barrier-induced abstinence: Number of oxycodone infusions and inactive and active lever presses during the 2-h sessions. d Relapse (incubation) tests: Number of active lever presses during the 30-min test sessions. During testing, active lever presses led to contingent presentation of the tone-light cue previously paired with oxycodone infusions during training, but not oxycodone infusions (extinction conditions). We tested separate groups of rats on either days 1 and 15, or days 1 and 30 (within-subjects testing). There were no group differences on day 1 testing in the two experimental conditions. Thus, for clarity of data presentation we combined the day 1 data of the two within-subjects test conditions. * Different from day 1. # Different from forced abstinence group on day 15 or day 30, p < 0.05. Data are mean ± SEM. Forced abstinence: day 1, n = 28 males/25 females; day 15, 14 males/13 females; and day 30, 14 males/12 females. Electric barrier-induced abstinence: day 1, 28 males/24 females; day 15, 14 males/12 females; and day 30, 14 males/12 females. See Fig. S1 for individual data.
展开▼
