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首页> 美国卫生研究院文献>Pharmaceuticals >Effects of a Formula Containing Two Types of Prebiotics Bifidogenic Growth Stimulator and Galacto-oligosaccharide and Fermented Milk Products on Intestinal Microbiota and Antibody Response to Influenza Vaccine in Elderly Patients: A Randomized Controlled Trial
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Effects of a Formula Containing Two Types of Prebiotics Bifidogenic Growth Stimulator and Galacto-oligosaccharide and Fermented Milk Products on Intestinal Microbiota and Antibody Response to Influenza Vaccine in Elderly Patients: A Randomized Controlled Trial

机译：包含两种益生元双歧杆菌生长刺激剂和半乳寡糖以及发酵乳制品的配方对老年患者肠道菌群和对流感疫苗的抗体反应的影响：一项随机对照试验。

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We investigated the effect of a formula containing two different prebiotics (bifidogenic growth stimulator and galacto-oligosaccharide) and fermented milk products on intestinal microbiota and antibody responses to an influenza vaccine in enterally fed elderly in-patients. Patients were administered either formula containing prebiotics and fermented milk products (group F: n = 12, 79.9 ± 9.5 years old) or standard formula (group C: n = 12, 80.7 ± 10.1 years old) via percutaneous endoscopic gastrostomy during a 14-week intervention period. Subjects were immunized with an influenza vaccine (A/H1N1, A/H3N2, and B) at week 4 of the intervention. Blood biochemical indices, intestinal bacteria populations and antibody titers were analyzed. Bifidobacterium counts increased significantly in group F compared with group C. The enhanced antibody titers against A/H1N1 were maintained in group F for a longer period compared with group C. The titers against A/H3N2 were unchanged between both groups, and those against B were significantly lower in group F than in group C, although few subjects had seroprotective titers against A/H3N2 and B. These results suggest that administration of the formula containing prebiotics and fermented milk products may maintain antibody titers for longer periods through the improvement of intestinal microbiota.
机译：我们研究了含有两种不同的益生元（双歧杆菌生长刺激剂和低聚半乳糖）和发酵乳制品的配方对肠内喂养的老年住院患者肠道菌群和流感疫苗抗体反应的影响。在14岁至14岁的儿童中，通过经皮内镜胃造口术向患者施用含益生元和发酵乳制品的配方食品（F组：n = 12，79.9±9.5岁）或标准配方食品（C组：n = 12，80.7±10.1岁）。周干预期。在干预的第4周，用流感疫苗（A / H1N1，A / H3N2和B）对受试者进行免疫。分析了血液生化指标，肠道细菌种群和抗体滴度。与C组相比，F组中双歧杆菌计数显着增加。与C组相比，F组中针对A / H1N1的抗体滴度保持了更长的时间。两组之间针对A / H3N2的滴度没有变化，而针对B组的尽管几乎没有受试者针对A / H3N2和B具有血清保护性滴度，但F组的C显着低于C组。这些结果表明，施用含益生元和发酵乳制品的配方可以通过改善肠道来保持抗体滴度更长的时间。微生物群

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