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Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis

机译：纵向药代动力学药物动力学生物标志物与药物敏感性肺结核肺结核的治疗结果相关：群体药代动力学药物动力学分析

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摘要

This study aims to explore relationships between baseline demographic covariates, plasma antibiotic exposure, sputum bacillary load, and clinical outcome data to help improve future tuberculosis (TB) treatment response predictions.

机译：本研究旨在探讨基线人群协变量，血浆抗生素暴露，痰大甲虫载荷和临床结果数据之间的关系，以帮助改善未来结核病（TB）治疗响应预测。

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期刊名称 Open Forum Infectious Diseases
作者
Frank Kloprogge; Henry C Mwandumba; Gertrude Banda; Mercy Kamdolozi; Doris Shani; Elizabeth L Corbett; Nadia Kontogianni; Steve Ward; Saye H Khoo; Geraint R Davies; Derek J Sloan;
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年(卷),期 2020(7),7
年度 2020
页码 ofaa218
总页数 11
原文格式 PDF
正文语种
中图分类病毒传染病;
关键词

机译：结果;药代动力学;药效学;标准治疗;结核病;

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专利

1. Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis [J] . Frank Kloprogge, Henry C Mwandumba, Gertrude Banda, Open Forum Infectious Diseases . 2020,第7期

机译：纵向药代动力学药物动力学生物标志物与药物敏感性肺结核肺结核的治疗结果相关：群体药代动力学药物动力学分析
2. Prediction of long-term treatment outcome in HCV following 24 day PEG-IFN alpha-2b therapy using population pharmacokinetic-pharmacodynamic mixture modeling and classification analysis [J] . Vinogradova Svetlana V., Zhudenkov Kirill V., Benson Neil, Journal of Theoretical Biology . 2015,第Null期

机译：使用群体药代动力学-药效学混合物建模和分类分析预测HCV在24天PEG-IFNα-2b治疗后的长期治疗结果
3. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis [J] . Nafees Ahmad, Shama D Ahuja, Onno W Akkerman, The Lancet . 2018,第10150期

机译：治疗肺多药抗结核成功结果相关：个体患者数据META分析
4. In silico assessment of nifedipine effects on human heart cells: Pharmacokinetic-pharmacodynamic analyses at the population level [C] . Mitra Abbasi, Sebastian Polak Computing in Cardiology Conference . 2017

机译：硝苯地平对人体心脏细胞影响的计算机评估：人群水平的药代动力学-药效学分析
5. Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation in the Development of Spectinamides, a Novel Class of Anti-Tuberculosis Agents [D] . Rathi, Chetan. 2017

机译：Spectinamides，一类新型抗结核药物开发中的转化药代动力学药效学建模和仿真
6. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis [O] . Nafees Ahmad, Shama D Ahuja, Onno W Akkerman, -1

机译：治疗与肺部多重耐药性肺结核的成功预后相关：个体患者数据荟萃分析
7. Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis [O] . Frank Kloprogge, Henry C Mwandumba, Gertrude Banda, 2020

机译：纵向药代动力学药物动力学生物标志物与药物敏感性肺结核肺结核的治疗结果相关：群体药代动力学药物动力学分析

Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis

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