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首页> 美国卫生研究院文献>Clinical Medicine Insights. Oncology >Nestin Expression as a Diagnostic and Prognostic Marker in Colorectal Cancer and Other Tumors
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Nestin Expression as a Diagnostic and Prognostic Marker in Colorectal Cancer and Other Tumors

机译：巢蛋白表达作为结肠直肠癌和其他肿瘤中的诊断和预后标志物

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摘要

Lung cancer, colon cancer, breast cancer, and prostate cancer are the leading causes of death in developed countries. Many cancers display non-specific signs in the early stage of the disease, thus making early diagnosis often difficult. We focused on nestin as a new biomarker of possible clinical importance in the early diagnosis and monitoring of cancer. The expression of nestin takes place at an early stage of neural differentiation, but no expression of the nestin gene can be revealed in normal, mature adult tissues. Nestin plays an important role in the development of the central nervous system and contributes to the organization and maintenance of cell shape. Nestin was found to be a marker of microvessel density, which in turn has proven to be a reliable prognostic factor for neoplastic malignancies in patients. Nestin expression correlates with an increased aggressiveness of tumor cells. The role of nestin in cancers of the colon and rectum, liver, central nervous system, lung cancer, breast cancer, melanoma, and other cancers has been reviewed in the literature. Associations between nestin expression and prognosis or drug-resistance may help in disease management. More research is needed to understand the molecular mechanisms of nestin expression and its role in possible targeted therapy.
机译：肺癌，结肠癌，乳腺癌和前列腺癌是发达国家死亡的主要原因。许多癌症在疾病的早期展示了非特异性迹象，从而使早期诊断常常困难。我们专注于Nestin作为可能在早期诊断和监测癌症中可能的临床重要性的新生物标志物。巢蛋白的表达在神经分化的早期发生，但在正常成熟的成人组织中没有巢蛋白基因的表达。 Nestin在中枢神经系统的发展中起着重要作用，并有助于组织和维持细胞形状。发现Nestin是微血管密度的标记，这反过来已被证明是患者肿瘤恶性肿瘤的可靠预后因素。巢蛋白表达与肿瘤细胞的侵略性增加相关。在文献中，巢蛋蛋白在结肠癌和直肠癌，肝脏，中枢神经系统，肺癌，乳腺癌，黑素瘤和其他癌症中的作用已被审查。 Nestin表达和预后或耐药性之间的关联可能有助于疾病管理。需要更多的研究来了解巢蛋白表达的分子机制及其在可能的靶向治疗中的作用。

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