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Colorectal Cancer Diagnostic Markers Using Colorectal Cancer Overexpression Genes

机译:大肠癌过表达基因的大肠癌诊断标记

摘要

PURPOSE: A marker for diagnosisng colon cancer is provided to accurately diagnose colon cancer in early time and determined metastasis and prognosis of colon cancer. CONSTITUTION: A marker for specifically diagnosing colon cancer is MAD2L1MAD2 mitotic arrest deficient-like 1(yeast)(GenBank No. NM_002358), CCNB1cyclin B1(GenBank No. NM_031966) or CSEILCSE1 chromosome segregation 1-like(yeast)(GenBank No. NM_001316). A composition for diagnosing colon cancer contains an agent for measuring mRNA or its protein level of MAD2L1, CCNB1 or CSEIL gene. The agent for measuring the mRNA level is a primer which specifically binds to the gene. A method for providing information for colon cancer diagnosis comprises: a step of measuring mRNA from a biological sample of a patient which possibly has colon cancer; and a step of comparing mRNA level with control group mRNA level.
机译:目的:提供一种诊断结肠癌的标志物,以在早期准确诊断结肠癌,并确定结肠癌的转移和预后。组成:专门诊断结肠癌的标志是MAD2L1MAD2有丝分裂阻滞缺陷样1(酵母)(GenBank编号NM_002358),CCNB1cyclin B1(GenBank编号NM_031966)或CSEILCSE1染色体分离1-like(酵母)(GenBank编号NM_001316) )。用于诊断结肠癌的组合物包含用于测量MAD2L1,CCNB1或CSEIL基因的mRNA或其蛋白水平的试剂。用于测量mRNA水平的试剂是与该基因特异性结合的引物。提供用于结肠癌诊断的信息的方法包括:从可能患有结肠癌的患者的生物样品中测量mRNA的步骤;比较mRNA水平和对照组mRNA水平的步骤。

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