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首页> 外文期刊>Oncology letters >Clinicopathological significance and impact on outcomes of the gene expression levels of IGF-1, IGF-2 and IGF-1R, IGFBP-3 in patients with colorectal cancer: Overexpression of the IGFBP-3 gene is an effective predictor of outcomes in patients with colorectal cancer
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Clinicopathological significance and impact on outcomes of the gene expression levels of IGF-1, IGF-2 and IGF-1R, IGFBP-3 in patients with colorectal cancer: Overexpression of the IGFBP-3 gene is an effective predictor of outcomes in patients with colorectal cancer

机译：临床病理意义和对结直肠癌患者IGFBP-3，IGFBP-3的基因表达水平的影响：IGFBP-3基因的过表达是结直肠癌患者的结果的有效预测因素 癌症

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摘要

The insulin-like growth factors (IGF) system is involved in tumor proliferation, invasion and metastasis in cancer. The current study investigated the association of IGF-1, IGF-2 and IGF-1 receptor (IGF-1R), IGF binding proteins type 3 (IGFBP-3) mRNA expression levels with clinicopathological characteristics and outcomes of 202 patients with untreated colorectal cancer (CRC). IGF-1, IGF-2, IGF-1R and IGFBP-3 mRNA expression levels were analyzed in surgical specimens of cancer tissues and adjacent normal mucosa cells using reverse transcription-quantitative polymerase chain reaction. The IGF-1R gene expression level was significantly higher in cancer tissue compared with adjacent normal mucosa. By contrast, IGF-1 gene expression levels were reduced in cancer tissue compared with normal mucosa. IGF-2 and IGFBP-3 gene expression levels did not differ significantly between cancer tissue and adjacent normal mucosa. As for the association of gene expression and clinicopathological characteristics, IGFBP-3 gene expression was significantly associated with lymph node metastasis. High IGFBP-3 gene expression was associated with poor 5-year overall survival compared with patients with low IGFBP-3 expression. Furthermore, IGFBP-3 gene expression was identified as an independent prognostic factor using multivariate analysis. Overexpression of the IGFBP-3 gene is considered an effective independent predictor of outcomes in patients with CRC.
机译：胰岛素样生长因子（IGF）系统参与癌症的肿瘤增殖，侵袭和转移。目前的研究研究了IGF-1，IGF-2和IGF-1受体（IGF-1R），IGF结合蛋白类型3（IGFBP-3）mRNA表达水平的关联，其具有202例未经治疗结直肠癌的临床病理特征和结果（CRC）。使用逆转录定量聚合酶链反应分析IGF-1，IGF-2，IGF-1R和IGFBP-3mRNA表达水平和相邻的正常粘膜细胞的手术标本。与相邻的正常粘膜相比，癌组织的IGF-1R基因表达水平显着较高。相比之下，与正常粘膜相比，癌组织中的IGF-1基因表达水平降低。 IGF-2和IGFBP-3基因表达水平在癌组织和邻近正常粘膜之间没有显着差异。对于基因表达和临床病理学特征的关联，IGFBP-3基因表达与淋巴结转移显着相关。与低IGFBP-3表达的患者相比，高IgFBP-3基因表达与5年的总体存活率有关。此外，使用多变量分析鉴定IGFBP-3基因表达作为独立预后因子。 IGFBP-3基因的过度表达被认为是CRC患者的有效独立预测因子。

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