Persistent Monotypic Plasma Cells with Absence of Neoplastic B Cell Component in a Treated Case of Waldenström Macroglobulinemia: A Sign of Residual Disease?

机译：在Waldenström巨球蛋白血症的治疗病例中没有肿瘤性B细胞成分的持久性单型浆细胞：残留疾病的征兆？

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摘要

Waldenström macroglobulinemia (WM) is a rare indolent variant of non- Hodgkin’s lymphoma characterised by lymphoplasmacytic infiltration of bone marrow (BM) associated with a serum IgM paraprotein. The WHO classification states that the neoplastic cells of WM usually are positive for monotypic surface immunoglobulin light chain, IgM, CD19, and CD20 and are negative for CD5, CD10, and CD23. Serum monoclonal protein detection by serum protein electrophoresis and bone marrow aspirate and biopsy are required for WM diagnosis, monitoring and response assessment. Pathologist must dissuade themselves from making a hasty decision on calling a complete response in WM when neoplastic B cell component is absent. Evaluation of clonality of any residual plasma cells must be done in all cases of WM to evaluate the presence and extent of residual or persistent disease. Role of additional therapy targeted at these residual plasma cells in WM can be evaluated as tools for achieving complete remission. Herein, we present a case of WM with residual monotypic plasmacytosis in BM, without B lymphocytes after therapy.

机译：Waldenström巨球蛋白血症（WM）是非霍奇金淋巴瘤的一种罕见的惰性变体，其特征是与血清IgM副蛋白相关的骨髓淋巴浆细胞浸润。 WHO分类表明，WM的肿瘤细胞通常对单型表面免疫球蛋白轻链，IgM，CD19和CD20呈阳性，而对CD5，CD10和CD23呈阴性。 WM诊断，监测和反应评估需要通过血清蛋白电泳，骨髓穿刺和活检来检测血清单克隆蛋白。当缺乏肿瘤性B细胞成分时，病理学家必须劝阻自己不要仓促做出决定，要求WM完全反应。在WM的所有病例中，必须对任何残留浆细胞的克隆性进行评估，以评估残留或持续性疾病的存在和程度。可以将针对WM中这些残留浆细胞的其他疗法的作用评估为实现完全缓解的工具。在这里，我们介绍了一个WM患者，其在BM中具有残留的单型浆细胞增多症，治疗后无B淋巴细胞。

著录项

期刊名称 Journal of Clinical and Diagnostic Research : JCDR
作者
Smeeta Gajendra; Ritesh Sachdev; Bhawna Jha; Shalini Goel; Tushar Sahni;
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作者单位

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年(卷),期 2014(8),11
年度 2014
页码 FD12–FD13
总页数 2
原文格式 PDF
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中图分类
关键词
Monotypic plasma cells Residual disease Waldenström macroglobulinemia;

机译：单型浆细胞;残留疾病;Waldenström巨球蛋白血症;

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1. Persistent Monotypic Plasma Cells with Absence of Neoplastic B Cell Component in a Treated Case of Waldenstr?m Macroglobulinemia: A Sign of Residual Disease? [J] . Smeeta Gajendra, Ritesh Sachdev, Bhawna Jha, Journal of Clinical and Diagnostic Research . 2014,第11期

机译：Waldenstr？巨球蛋白血症的治疗病例中不存在赘生性B细胞成分的持久性单型浆细胞：是否存在残留疾病？
2. Cutaneous macroglobulinosis with monotypic plasma cells: A specific manifestation of Waldenstr?m macroglobulinemia [J] . SpicknallK.E., DubasL.E., MutasimD.F. Journal of cutaneous pathology . 2013,第5期

机译：具有单型浆细胞的皮肤巨球蛋白病：Waldenstr？m巨球蛋白血症的一种特殊表现
3. Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapy. [J] . Barakat FH, Medeiros LJ, Wei EX, American journal of clinical pathology. . 2011,第3期

机译：瓦尔登斯通巨球蛋白血症患者在治疗后残留的单型浆细胞。
4. A Multiscale System for Injectable Co-delivery of EGF and Stem Cells to Treat Ischemic Diseases [C] . Hai Wang, Xiaoming He Society for Biomaterials annual meeting and exposition . 2018

机译：EGF和干细胞可注射共同递送的多尺度系统，用于治疗缺血性疾病
5. Associations of T-cell phenotypes with persistent oral thrush at CD4 positive cell counts greater than 500 per cubic millimeter and their interactions with progression of HIV disease (Immune deficiency). [D] . Foster, Virginia Brown. 2001

机译：T细胞表型与持续口鹅口疮在CD4阳性细胞数上的关联大于每立方毫米500，以及它们与HIV疾病进展（免疫缺陷）的相互作用。
6. Absence of BRAF exon 15 mutations in multiple myeloma and Waldenström’s macroglobulinemia questions its validity as a therapeutic target in plasma cell neoplasias [O] . Eleftheria Hatzimichael, Samuel Murray, Evangelos Briasoulis 2013

机译：多发性骨髓瘤缺乏BRAF外显子15突变Waldenström巨球蛋白血症质疑其作为浆细胞瘤形成治疗靶点的有效性
7. Persistent Monotypic Plasma Cells with Absence of Neoplastic B Cell Component in a Treated Case of Waldenström Macroglobulinemia: A Sign of Residual Disease? [O] . Smeeta Gajendra 2014

机译：持续的单型血浆细胞，在韦尔登斯特罗姆大葡萄球菌血症的治疗情况下没有肿瘤B细胞组分：残留疾病的迹象？

Persistent Monotypic Plasma Cells with Absence of Neoplastic B Cell Component in a Treated Case of Waldenström Macroglobulinemia: A Sign of Residual Disease?

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