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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Persistent Monotypic Plasma Cells with Absence of Neoplastic B Cell Component in a Treated Case of Waldenstr?m Macroglobulinemia: A Sign of Residual Disease?
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Persistent Monotypic Plasma Cells with Absence of Neoplastic B Cell Component in a Treated Case of Waldenstr?m Macroglobulinemia: A Sign of Residual Disease?

机译：Waldenstr？巨球蛋白血症的治疗病例中不存在赘生性B细胞成分的持久性单型浆细胞：是否存在残留疾病？

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摘要

Waldenstr?m macroglobulinemia (WM) is a rare indolent variant of non- Hodgkin?s lymphoma characterised by lymphoplasmacytic infiltration of bone marrow (BM) associated with a serum IgM paraprotein. The WHO classification states that the neoplastic cells of WM usually are positive for monotypic surface immunoglobulin light chain, IgM, CD19, and CD20 and are negative for CD5, CD10, and CD23. Serum monoclonal protein detection by serum protein electrophoresis and bone marrow aspirate and biopsy are required for WM diagnosis, monitoring and response assessment. Pathologist must dissuade themselves from making a hasty decision on calling a complete response in WM when neoplastic B cell component is absent. Evaluation of clonality of any residual plasma cells must be done in all cases of WM to evaluate the presence and extent of residual or persistent disease. Role of additional therapy targeted at these residual plasma cells in WM can be evaluated as tools for achieving complete remission. Herein, we present a case of WM with residual monotypic plasmacytosis in BM, without B lymphocytes after therapy.
机译：Waldenstrm巨球蛋白血症（WM）是非霍奇金淋巴瘤的一种罕见的惰性变体，其特征在于与血清IgM副蛋白相关的骨髓（BM）的淋巴浆细胞浸润。 WHO分类表明，WM的肿瘤细胞通常对单型表面免疫球蛋白轻链，IgM，CD19和CD20呈阳性，而对CD5，CD10和CD23呈阴性。 WM诊断，监测和反应评估需要通过血清蛋白电泳，骨髓穿刺和活检来检测血清单克隆蛋白。当缺乏肿瘤性B细胞成分时，病理学家必须劝阻自己不要仓促做出决定，要求WM完全反应。在WM的所有病例中，必须对任何残留浆细胞的克隆性进行评估，以评估残留或持续性疾病的存在和程度。可以将针对WM中这些残留浆细胞的其他疗法的作用评估为实现完全缓解的工具。在这里，我们介绍了一个WM病例，其在BM中具有残留的单型浆细胞增多症，治疗后无B淋巴细胞。

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