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Oxygen Permeability of Silk Fibroin Hydrogels and Their Use as Materials for Contact Lenses: A Purposeful Analysis

机译:丝纤维素水凝胶的氧气渗透性及其用作隐形眼镜的材料:有目的的分析

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摘要

Fibroin is a fibrous protein that can be conveniently isolated from the silk cocoons produced by the larvae of Bombyx mori silk moth. In its form as a hydrogel, Bombyx mori silk fibroin (BMSF) has been employed in a variety of biomedical applications. When used as substrates for biomaterial-cells constructs in tissue engineering, the oxygen transport characteristics of the BMSF membranes have proved so far to be adequate. However, over the past three decades the BMSF hydrogels have been proposed episodically as materials for the manufacture of contact lenses, an application that depends on substantially elevated oxygen permeability. This review will show that the literature published on the oxygen permeability of BMSF is both limited and controversial. Additionally, there is no evidence that contact lenses made from BMSF have ever reached commercialization. The existing literature is discussed critically, leading to the conclusion that BMSF hydrogels are unsuitable as materials for contact lenses, while also attempting to explain the scarcity of data regarding the oxygen permeability of BMSF. To the author’s knowledge, this review covers all publications related to the topic.
机译:纤维素是一种纤维素蛋白质,可以方便地从由Bombyx Mori丝绸蛾的幼虫产生的丝绸茧中分离。在其作为水凝胶的形式中,Bombyx Mori丝素蛋白(BMSF)已在各种生物医学应用中使用。当用作组织工程中的生物材料构建体的底物时,迄今已证明BMSF膜的氧传输特性是足够的。然而,在过去的三十年中,已经将BMSF水凝胶作为用于制造隐形眼镜的材料,其应用取决于基本上升高的透氧性。本综述将显示发表于BMSF氧气性的文献既有限又有争议。此外,没有证据表明,由BMSF制造的隐形眼镜曾达到商业化。本现有文献批判性地讨论,导致BMSF水凝胶不适合作为隐形眼镜的材料,同时还试图解释关于BMSF的氧气渗透性的数据的稀缺性。对提交人的知识,本综述涵盖了与该主题相关的所有出版物。

著录项

  • 期刊名称 Gels
  • 作者

    Traian V. Chirila;

  • 作者单位
  • 年(卷),期 2021(7),2
  • 年度 2021
  • 页码 58
  • 总页数 12
  • 原文格式 PDF
  • 正文语种
  • 中图分类
  • 关键词

    机译:丝素蛋白;膜;生物材料;氧气渗透性;隐形眼镜;

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