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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone
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Synthesis and Evaluation of AlgNa-g-Poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

机译：藻类-G-聚（QCL-CO-HEMA）水凝胶作为软骨细胞增殖平台的合成与评价及β甲基替代酮的控制释放

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Hydrogels obtained from combining different polymers are an interesting strategy for developing controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels for these biomedical applications was evaluated. Hydrogels were synthesized by free-radical polymerization using a different concentration of the components. The hydrogels were characterized by Fourier transform-infrared spectroscopy, scanning electron microscopy, and a swelling degree. Betamethasone release as well as the in vitro cytocompatibility with chondrocytes and fibroblast cells were also evaluated. Scanning electron microscopy confirmed the porous surface morphology of the hydrogels in all cases. The swelling percent was determined at a different pH and was observed to be pH-sensitive. The controlled release behavior of betamethasone from the matrices was investigated in PBS media (pH = 7.4) and the drug was released in a controlled manner for up to 8 h. Human chondrocytes and fibroblasts were cultured on the hydrogels. The MTS assay showed that almost all hydrogels are cytocompatibles and an increase of proliferation in both cell types after one week of incubation was observed by the Live/Dead® assay. These results demonstrate that these hydrogels are attractive materials for pharmaceutical and biomedical applications due to their characteristics, their release kinetics, and biocompatibility.
机译：从组合不同的聚合物获得的水凝胶是用于开发控释系统平台和组织工程支架的有趣策略。在该研究中，评估了藻酸钠-G-（QCl-Co-HEMA）水凝胶对这些生物医学应用的适用性。使用不同浓度的组分通过自由基聚合合成水凝胶。通过傅里叶变换 - 红外光谱，扫描电子显微镜和溶胀度表征水凝胶。还评价了βOsone释放以及与软骨细胞和成纤维细胞的体外细胞相容性。扫描电子显微镜确认了所有情况下水凝胶的多孔表面形态。溶胀百分比在不同的pH下测定，并观察到pH敏感性。在PBS培养基（pH = 7.4）中研究了来自基质倍甲段的受控释放行为，并以受控的方式释放药物最多8小时。人软骨细胞和成纤维细胞在水凝胶上培养。 MTS测定表明，几乎所有水凝胶是细胞胶质组分，并且在通过Live /Dead®MaSay观察到一周的孵育后两种细胞类型中的增殖增加。这些结果表明，由于其特征，其释放动力学和生物相容性，这些水凝胶是药物和生物医学应用的吸引力。

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