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首页> 美国卫生研究院文献>Journal of the Endocrine Society >Effects of Extracts of Plathymenia Reticulata Benth and Azadirachta Indica (Neem) in Glycated Hemoglobin in Diabetic Rats
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Effects of Extracts of Plathymenia Reticulata Benth and Azadirachta Indica (Neem) in Glycated Hemoglobin in Diabetic Rats

机译：吡酰胺蛋白替氏蛋白酶（Neem）在糖尿病大鼠血糖血红蛋白中提取物的影响

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Introduction: The Plathymenia reticulata benth is a herbal medicine that has properties of pancreatic islet hyperplasia and glycemic control in diabetic rats. Neem (Azadirachta indica A. Juss, Meliaceae) is a tree native to India that has several medicinal effects. Goal: To verify the effect of glycated hemoglobin levels in rats with type 1 and non-diabetic diabetes mellitus, in treatment with Plathymenia Reticulata Benth, Neem and the association between them. compared to insulin. Methodology: Diabetes was induced by intraperitoneal streptozotocin (65mg/kg) administration after a 24-hour fast. The diagnosis was made using a blood glucose value above 200mg/dl. The study was conducted in 60 male adult Wistar rats, weighing between 180 and 220 grams, divided into 9 groups, between diabetics (DM) and non-diabetic controls (NdM), and treated with Neem (300 mg/kg), cold aqueous extract of Plathymenia (100 mg/kg), water (negative control) and insulin (3 IU/day) - positive control; and association between plants. The treatment was performed by orogastric gavage for a period of 28 consecutive days, and weekly weight and daily feed intake were performed. Data were analyzed using ANOVA and Tukey-Kramer’s pos-hoc test, with a significance level of 5% using the SPSS25.0 software. The results are expressed on average ± EPM. Results: There was a significant difference in glycated hemoglobin levels in rats submitted to insulin treatment (6.18 ± 0.36) compared to those submitted to treatment with Neem (10.12 ± 1.29, p=0.047), Plathymenia+Neem (12.09 ± 0.38, p=0.006) and water (10.86 ± 1.26, p=0.015). However, no significant difference was observed between the reduction in glycated hemoglobin levels in the groups submitted to insulin treatment compared to the group treated with Plathymenia (7.30 ± 0.68, p=0.911). Conclusion: The results allow us to evaluate a non-inferiority condition in relation to the use of the Plathymenia when compared to treatment with insulin therapy, positive control in the treatment of type 1 diabetes mellitus. The Plathymeniamay present as a herbal option in the treatment of the disease and prevention of complications. Further studies are necessary to evaluate the effect of the extract on other aspects related to the pathology.
机译：简介：Plathymenia TeariCulata Benth是一种草药，具有糖尿病大鼠胰岛增生和血糖控制的性质。 Neem（Azadirachta indica A.Juss，Meliaceae）是一种原产于印度的树，有几种药用作用。目标：验证用1型和非糖尿病糖尿病的大鼠糖化血红蛋白水平的影响，用普拉塔尼亚替补型瘦身，NEEM和它们之间的关联治疗。与胰岛素相比。方法论：在快速24小时后，通过腹膜内链脲佐菌素（65mg / kg）给药诱导糖尿病。使用血糖值超过200mg / dl进行诊断。该研究在60只雄性成人Wistar大鼠中进行，称重180和220克，分为9组，糖尿病（DM）和非糖尿病对照（NDM）之间，并用Neem（300mg / kg），冷水处理普拉塔米蛋白提取物（100mg / kg），水（阴性对照）和胰岛素（3 iu / day） - 阳性对照;和植物之间的关联。治疗通过蠕动连续28天进行，每周重量和每日进料摄入量进行。使用ANOVA和TUKEY-KRAMER的POOC测试分析数据，使用SPSS25.0软件具有5％的显着性水平。结果平均表示为±EPM。结果：与提交胰岛素治疗的大鼠（6.18±0.36）相比，与Neem治疗的那些（6.12±1.29，P = 0.047），Plathymenia + Neem（12.09±0.38，P = 0.006）和水（10.86±1.26，p = 0.015）。然而，与用过甲脑治疗的组（7.30±0.68，p = 0.911），在提交给胰岛素治疗的组中的血糖血红蛋白水平的降低之间没有观察到显着差异。结论：与胰岛素治疗治疗相比，结果允许我们在与甲状腺治疗的治疗相比，治疗1型糖尿病患者的阳性对照，允许我们评估非较低病症。 Plathymenayay作为治疗疾病和预防并发症的草药选择。进一步的研究是为了评估提取物对与病理学相关的其他方面的影响。

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