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首页> 美国卫生研究院文献>FEBS Open Bio >Dysbiosis of gut microbiota after cholecystectomy is associated with non‐alcoholic fatty liver disease in mice
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Dysbiosis of gut microbiota after cholecystectomy is associated with non‐alcoholic fatty liver disease in mice

机译：胆囊切除术后肠道微生物瘤的消化不良与小鼠的非酒精脂肪肝病有关

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Increasing evidence suggests that cholecystectomy is an independent risk factor for non‐alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms that lead to hepatic lipid deposition after cholecystectomy are unclear. In this study, adult male C57BL/6J mice that underwent a cholecystectomy or sham operation were fed either a high‐fat diet (HFD) or a chow diet for 56 days. Significantly increased steatohepatitis, liver/body weight ratio, hepatic triglycerides, and glucose intolerance were observed in postcholecystectomy mice fed the HFD. Notable alterations in the composition of gut microbiota after cholecystectomy were observed in both HFD‐ and chow‐diet‐fed mice. Our results indicate that cholecystectomy alters the gut microbiota profile, which might contribute to the development of NAFLD in mice.
机译：越来越多的证据表明，胆囊切除术是非酒精性脂肪肝病（NAFLD）的独立危险因素。然而，在胆囊切除术后导致肝脂沉积导致肝脂沉积的潜在机制尚不清楚。在本研究中，经过胆囊切除术或假手术的成年雄性C57BL / 6J小鼠喂食高脂饮食（HFD）或味道饮食56天。在喂养HFD的后骨膜切除术小鼠中观察到显着提高的脱脂性炎，肝脏/体重比，肝甘油三酯和葡萄糖不耐受。在胆囊切除术后，在HFD-和Chow饮食喂食小鼠中观察到肠道微生物组成的显着改变。我们的结果表明，胆囊切除术改变了肠道微生物群型，这可能导致小鼠中NAFLD的发育。

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