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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Bisphosphonate-Based Conjugates and Derivatives as Potential Therapeutic Agents in Osteoporosis Bone Cancer and Metastatic Bone Cancer
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Bisphosphonate-Based Conjugates and Derivatives as Potential Therapeutic Agents in Osteoporosis Bone Cancer and Metastatic Bone Cancer

机译：基于双膦酸酯的缀合物和衍生物作为骨质疏松症骨癌和转移性骨癌的潜在治疗剂

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Metastatic bone cancer occurs in every type of cancer but is prevalent in lung, breast, and prostate cancers. These metastases can cause extensive morbidity, including a range of skeletal-related events, often painful and linked with substantial hospital resource usage. The treatment used is a combination of chemotherapy and surgery. However, anticancer drugs are still limited due to severe side effects, drug resistance, poor blood supply, and non-specific drug uptake, necessitating high toxic doses. Bisphosphonates are the main class of drugs utilized to inhibit metastatic bone cancer. It is also used for the treatment of osteoporosis and other bone diseases. However, bisphosphonate also suffers from serious side effects. Thus, there is a serious need to develop bisphosphonate conjugates with promising therapeutic outcomes for treating metastatic bone cancer and osteoporosis. This review article focuses on the biological outcomes of designed bisphosphonate-based conjugates for the treatment of metastatic bone cancer and osteoporosis.
机译：转移性骨癌发生在每种类型的癌症中，但在肺癌，乳腺和前列腺癌中普遍存在。这些转移可以引起大量发病率，包括一系列与骨骼相关的事件，通常与大量医院资源使用相连。使用的治疗是化疗和手术的组合。然而，由于严重的副作用，耐药性，血液供应不良和非特异性药物摄取，抗癌药物仍然有限。双膦酸盐是用于抑制转移性骨癌的主要药物。它还用于治疗骨质疏松症和其他骨病。然而，双膦酸盐也存在严重的副作用。因此，存在具有对治疗转移性骨癌和骨质疏松症的有前途的治疗结果进行双膦酸酯缀合物。该综述文章侧重于设计的基于双膦酸酯的缀合物的生物学结果，用于治疗转移性骨癌和骨质疏松症。

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