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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Coating with Hypertonic Saline Improves Virus Protection of Filtering Facepiece Manyfold—Benefit of Salt Impregnation in Times of Pandemic
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Coating with Hypertonic Saline Improves Virus Protection of Filtering Facepiece Manyfold—Benefit of Salt Impregnation in Times of Pandemic

机译：高渗盐水涂层改善了过滤面板的病毒保护多折叠盐浸渍的福利

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Recently, as is evident with the COVID-19 pandemic, virus-containing aerosols can rapidly spread worldwide. As a consequence, filtering facepieces (FFP) are essential tools to protect against airborne viral particles. Incorrect donning and doffing of masks and a lack of hand-hygiene cause contagion by the wearers’ own hands. This study aimed to prove that hypertonic saline effectively reduces the infectious viral load on treated masks. Therefore, a hypertonic salt solution´s protective effect on surgical masks was investigated, specifically analyzing the infectivity of aerosolized Alphacoronavirus 1 in pigs (Transmissible Gastroenteritis Virus (TGEV)). Uncoated and hypertonic salt pre-coated FFPs were sprayed with TGEV. After drying, a defined part of the mask was rinsed with the medium, and the eluent was used for the infection of a porcine testicular cell line. Additionally, airborne microorganisms´ long-term infectivity of sodium-chloride in phosphate-buffered saline comprising 5% saccharose was investigated. In the results from an initial Median Tissue Culture Infectious Dose, infection rate of TGEV was minimally reduced by untreated FFP. In contrast, this could be reduced by a factor of 104 if FFPs were treated with hypertonic salt solutions. Airborne pathogens did not contaminate the growth medium if salt concentrations exceeded 5%. We conclude that hypertonic saline is a vital tool for anti-virus protection, exponentially improving the impact of FFPs.
机译：最近，与Covid-19大流行显而易见的，含有病毒的气溶胶可以在全球范围内快速传播。因此，过滤面部（FFP）是保护防止空气传播病毒颗粒的必要工具。睡眠不正确和落下面具和缺乏手卫生事件导致佩戴者自己的手蔓延。本研究旨在证明高渗盐水有效地降低了处理过的腮腺炎的传染病病毒载量。因此，研究了高渗盐溶液对外科口罩的保护作用，特别是分析猪的雾化alphoronavirus 1的感染性（传染性胃肠炎病毒（TGEV））。用TGEV喷涂未涂覆和高渗盐预涂覆的FFP。干燥后，用培养基冲洗掩模的限定部分，用洗脱液用于感染猪睾丸线。另外，研究了包含5％蔗糖的磷酸盐缓冲盐水中氯化钠的空气传播微生物的长期感染性。在初始中位组织培养的结果中，通过未处理的FFP，TGEV的感染率最小降低。相反，如果用高渗盐溶液处理FFP，这可以减少104倍。如果盐浓度超过5％，则空气传播的病原体没有污染生长培养基。我们得出结论，高渗盐水是抗病毒保护的重要工具，指数提高FFP的影响。

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