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首页> 美国卫生研究院文献>Neuropsychopharmacology >Chronic social defeat stress impairs goal-directed behavior through dysregulation of ventral hippocampal activity in male mice
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Chronic social defeat stress impairs goal-directed behavior through dysregulation of ventral hippocampal activity in male mice

机译：慢性社会失败应力损害雄性小鼠中腹部海马活性的腹部海马活性的目标定向行为

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a Schematic illustration of the FR-5 schedule. b Experimental schedule (upper) and schematic illustration (lower) of operant training during repeated social defeat stress (R-SDS). c The effects of repeated social defeat stress (n = 36, black circles) on first lever-press latency (top), completion latency of FR-5 (middle), and food collection latency (bottom) in the FR-5 task. Controls (without R-SDS, n = 12, white circles) showed stable task performance. Two-way repeated-measures ANOVA confirmed significant group × session interactions on first lever-press latency (p = 0.004) and completion latency (p = 0.041) but not food collection latency (p = 0.737). Bars represents s.e.m. Asterisks (*p < 0.01) represent significant t-test with Bonferroni correction (compared with the same time point). d Mice receiving R-SDS exhibited a gradual increase in incomplete trials in the FR-5 task (n = 36 mice) compared with controls. Two-way repeated-measures ANOVA confirmed a significant group × session interactions on incomplete trials (p = 0.031). *p < 0.01, t-test with Bonferroni correction. e Histogram of incomplete trial% at SDS day 10 indicates a bimodal distribution. Defeated mice were categorized as susceptible (n = 16) or resilient (n = 20) based on incomplete trials (k-means clustering, k = 2). Threshold value dividing susceptible and resilient groups was 11.3%. f First lever-press latency and completion latency in susceptible mice were increased (resilient mice, n = 20; susceptible mice, n = 16 mice), but the food collection latency in FR-5 task was not changed. *p < 0.05 (t-test). g The percentage of incomplete trials did not correlate with SI ratio (n = 36 mice).
机译：FR-5时间表的示意图。 B重复社会失败压力（R-SDS）期间操作培训的实验时间表（上部）和示意图（下）。 C反复社会失败应力（n = 36，黑圆圈）对FR-5任务中FR-5（中间）的第一个杠杆压力延迟（顶部），完成延迟（底部）的效果。控制（没有R-SDS，N = 12，白色圆圈）显示了稳定的任务性能。双向重复测量Anova确认了第一杆压力延迟（P = 0.004）和完成延迟（P = 0.041）而不是食物收集延迟（P = 0.737）上的显着组×会话相互作用（P = 0.737）。酒吧代表S.E.M.星号（* P <0.01）表示具有Bonferroni校正的显着T检验（与同一时间点相比）。与对照相比，接受R-SDS接受R-SDS的小鼠在FR-5任务（N = 36只小鼠）中表现出不完全试验的逐渐增加。双向重复措施Anova证实了不完整试验的显着组×会话相互作用（P = 0.031）。 * P <0.01，T检验与Bonferroni校正。在SDS第10天处不完全试验的E直方图表示双峰分布。基于不完全试验（K-means聚类，k = 2），将被击败的小鼠分类为敏感（n = 16）或弹性（n = 20）。分割敏感和弹性组的阈值为11.3％。 F第一杠杆压力延迟和易感小鼠的完井等待时间（有易感小鼠，n = 20;易感小鼠，n = 16只小鼠），但FR-5任务中的食物收集延迟没有改变。 * P <0.05（T检验）。 g不完全试验的百分比与Si比（n = 36只小鼠）相关。

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