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Beyond Nutrient Deficiency—Opportunities to Improve Nutritional Status and Promote Health Modernizing DRIs and Supplementation Recommendations

机译:除了营养缺乏 - 改善营养状况的机会促进卫生现代化艺术会和补充建议

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摘要

The US Dietary Guidelines for Americans (DGA) provide dietary recommendations to meet nutrient needs, promote health, and prevent disease. Despite 40 years of DGA, the prevalence of under-consumed nutrients continues in the US and globally, although dietary supplement use can help to fill shortfalls. Nutrient recommendations are based on Dietary Reference Intakes (DRIs) to meet the nutrient requirements for nearly all (97 to 98 percent) healthy individuals in a particular life stage and gender group and many need to be updated using current evidence. There is an opportunity to modernize vitamin and mineral intake recommendations based on biomarker or surrogate endpoint levels needed to ‘prevent deficiency’ with DRIs based on ranges of biomarker or surrogate endpoints levels that support normal cell/organ/tissue function in healthy individuals, and to establish DRIs for bioactive compounds. We recommend vitamin K and Mg DRIs be updated and DRIs be established for lutein and eicosapentaenoic and docosahexaenoic acid (EPA + DHA). With increasing interest in personalized (or precision) nutrition, we propose greater research investment in validating biomarkers and metabolic health measures and the development and use of inexpensive diagnostic devices. Data generated from such approaches will help elucidate optimal nutrient status, provide objective evaluations of an individual’s nutritional status, and serve to provide personalized nutrition guidance.
机译:美国美国人饮食准则(DGA)提供膳食建议,以满足营养需求,促进健康,预防疾病。尽管40年的DGA,但营养不足的营养素的患病率在美国和全球范围内持续,尽管膳食补充剂可以帮助填补不足。营养建议基于膳食参考摄入量(DRIS),以满足特定生命阶段和性别集团的几乎所有(97至98%)健康个体的营养需求,并且许多需要使用当前证据进行更新。基于生物标志物的范围或替代终点水平,基于生物标志物或替代终点水平的生物标志物或替代终点水平,有机会将维生素和矿物摄入量现代化,基于生物标志物或替代终点水平,以支持健康个体的正常细胞/器官/组织功能,以及建立生物活性化合物的滴。我们建议更新维生素K和MG DRIS,并为叶黄素和eicosapentaenoic和Docosahexeno的酸(EPA + DHA)建立DRIS。随着对个性化(或精确)营养的兴趣越来越大,我们提出了更大的研究投资来验证生物标志物和代谢健康措施以及廉价诊断设备的开发和使用。这些方法产生的数据将有助于阐明最佳营养状况,提供对个体的营养状况的客观评估,并提供提供个性化营养指导。

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