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首页> 美国卫生研究院文献>International Wound Journal >Insulin and hypertonic glucose in the management of aseptic fat liquefaction of post‐surgical incision: a meta‐analysis and systematic review
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Insulin and hypertonic glucose in the management of aseptic fat liquefaction of post‐surgical incision: a meta‐analysis and systematic review

机译：胰岛素和高渗葡萄糖在手术切口无菌脂肪液化中的管理中：META分析和系统审查

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A meta‐analysis and systematic review assessing randomised controlled trials (RCTs) was sought to determine whether subcutaneous injection of insulin with hypertonic glucose promotes healing in postoperative incisions with aseptic fat liquefaction. We searched the Cochrane library, Pubmed, EMBASE, National Science Digital Library (NSDL) and China Biological Medicine Database (CBMdisc) for literature published from 1 January 1990 to 30 September 2011. RCTs that evaluated subcutaneous injection of insulin with hypertonic glucose as a treatment for postoperative wound with fat liquefaction were sought. Wound healing was the primary endpoint. Jadad score and Cochrane Collaboration's tool were used for assessing quality of studies and risk of bias. We abstracted data regarding time to wound healing, cost and adverse effects. The random‐effects inverse variance model was used for all analyses using weighted mean difference and 95% confidence interval. Eight trials (414 participants) were identified that met the inclusion criteria. Subcutaneous injection of insulin with hypertonic glucose significantly reduces time to healing by 6·33 days compared with conventional drainage, with less cost. There was no report concerning adverse effects. Subcutaneous injection of insulin with hypertonic glucose may improve the healing process in postoperative wounds with aseptic fat liquefaction.
机译：评估随机对照试验（RCTS）的荟萃分析和系统审查是试图确定皮下注射高渗葡萄糖的胰岛素，促进术后切口与无菌脂肪液化的愈合。我们在2011年1月1日至2011年9月30日发表的文学中搜索了Cochrane图书馆，PubMed，Embase，国家科学数字图书馆（NSDL）和中国生物医学数据库（CBMDISC）。RCTS评估了用高渗葡萄糖作为治疗的皮下注射胰岛素寻求乳脂液的术后伤口。伤口愈合是主要终点。 Jadad得分和Cochrane Collaboration的工具用于评估研究质量和偏见风险。我们向伤口愈合，成本和不利影响抽象了关于时间的数据。使用加权平均差异和95％置信区间的所有分析使用随机效应逆差模型。确定八项试验（414名参与者），符合纳入标准。具有高渗葡萄糖的皮下注射胰岛素明显减少了与常规引流相比愈合的时间缩短了6·33天，成本较低。没有关于不利影响的报告。具有高渗葡萄糖的皮下注射胰岛素可以通过无菌脂肪液化改善术后伤口中的愈合过程。

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