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首页> 美国卫生研究院文献>Journal of Clinical Biochemistry and Nutrition >Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population
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Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population

机译：在日本人群中使用16S基因测序比较肥胖人群和瘦人群的肠道微生物群落

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Altered gut microbial ecology contributes to the development of metabolic diseases including obesity. In this study, we performed 16S rRNA sequence analysis of the gut microbiota profiles of obese and lean Japanese populations. The V3–V4 hypervariable regions of 16S rRNA of fecal samples from 10 obese and 10 lean volunteers were sequenced using the Illumina MiSeqTMII system. The average body mass index of the obese and lean group were 38.1 and 16.6 kg/m2, respectively (p<0.01). The Shannon diversity index was significantly higher in the lean group than in the obese group (p<0.01). The phyla Firmicutes and Fusobacteria were significantly more abundant in obese people than in lean people. The abundance of the phylum Bacteroidetes and the Bacteroidetes/Firmicutes ratio were not different between the obese and lean groups. The genera Alistipes, Anaerococcus, Corpococcus, Fusobacterium and Parvimonas increased significantly in obese people, and the genera Bacteroides, Desulfovibrio, Faecalibacterium, Lachnoanaerobaculum and Olsenella increased significantly in lean people. Bacteria species possessing anti-inflammatory properties, such as Faecalibacterium prausnitzii, increased significantly in lean people, but bacteria species possessing pro-inflammatory properties increased in obese people. Obesity-associated gut microbiota in the Japanese population was different from that in Western people.
机译：肠道微生物生态学的改变导致包括肥胖在内的新陈代谢疾病的发展。在这项研究中，我们对肥胖和瘦日本人群的肠道菌群谱进行了16S rRNA序列分析。使用Illumina MiSeq TM II系统对10位肥胖和10位瘦志愿者的粪便样品的16S rRNA的V3-V4高变区进行测序。肥胖和瘦肉组的平均体重指数分别为38.1和16.6 kg / m 2 （p <0.01）。瘦肉组的Shannon多样性指数显着高于肥胖组（p <0.01）。与瘦人相比，肥胖人群中的坚韧菌门和梭菌细菌含量明显更高。肥胖组和瘦肉组的拟杆菌门的丰度和拟杆菌/冷杉的比率没有差异。在肥胖人群中，Alistipes，Anaerococcus，Corpococcus，Fusobacter和Parvimonas属显着增加，而Bacteroides，Desulfovibrio，Faecalibacterium，Lachnoanaerobaculum和Olsenella属在肥胖人群中显着增加。具有消炎特性的细菌，例如普氏嗜藻杆菌，在瘦人中显着增加，而具有促炎特性的细菌在肥胖者中则增加。日本人群中与肥胖相关的肠道菌群与西方人不同。

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