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首页> 美国卫生研究院文献>Journal of Cancer >Risk Factors Associated with Precancerous Lesions of Esophageal Squamous Cell Carcinoma: a Screening Study in a High Risk Chinese Population
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Risk Factors Associated with Precancerous Lesions of Esophageal Squamous Cell Carcinoma: a Screening Study in a High Risk Chinese Population

机译：食管鳞状细胞癌癌前病变相关的危险因素：高危中国人群的筛选研究

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>Background: Esophageal squamous cell carcinoma (ESCC) has been having a high mortality rate in China. Most patients are diagnosed in advanced stages, leading to the poor prognosis and low 5-year survival rate. Detection of precancerous lesions or early cancers is the key to improving this situation. Although previous studies have identified some risk factors for ESCC, they rarely paid attention to the premalignant esophageal lesions. We thus initiated a population-based screening study aiming to assess risk factors associated with esophageal precancerous lesions (EPLs) in a high risk Chinese population.>Methods: From September 2013 to July 2015, we screened residents aged 40-69 years from 53 randomly selected communities in Feicheng, China (n = 5076). Each participant went through questionnaire interview, physical examination, endoscopy and biopsy. Using logistic regression, we compared participants with EPLs to that with normal esophageal mucosa for finding potential risk factors of EPLs.>Results: A total of 570 participants were diagnosed with EPLs. We observed no association between EPLs and tobacco smoking or alcohol consumption in unadjusted or adjusted model. In the adjusted model, the OR (95% CI) was 1.84 (1.18-2.89) for people of drinking shallow-well water comparing to people who was drinking tap-water. In a comparison of participants with good oral health, the ESD/ESCC ORs (95% CI) for those with very poor or poor oral health, were 1.78 (1.28-2.49) and 1.58 (1.16-2.15) respectively. However, no statistical significance was observed after adjustment. Moreover, cereal straw heating (OR= 1.74, 95% CI: 0.90-3.36, P=0.099) may lead to increased risk of EPLs.>Conclusion: In Feicheng population, tobacco smoking or alcohol consumption may not be risk factors of EPLs. Low-quality drinking water raised the EPLs risk. Bad house heating materials, such as cereal straw, may lead to high EPLs risk.
机译：>背景：食管鳞状细胞癌（ESCC）在中国的死亡率一直很高。大多数患者被诊断为晚期，导致预后不良和5年生存率低。检测癌前病变或早期癌症是改善这种情况的关键。尽管先前的研究已经确定了食管鳞癌的一些危险因素，但他们很少关注食管癌前病变。因此，我们启动了一项基于人群的筛查研究，旨在评估与高风险中国人群食道癌前病变（EPL）相关的危险因素。>方法：从2013年9月至2015年7月，我们筛查了40岁的居民来自中国肥城53个社区的-69年（n = 5076）。每位参与者都接受了问卷调查，身体检查，内窥镜检查和活检。通过逻辑回归，我们将具有EPL的参与者与正常食管粘膜的参与者进行了比较，以发现EPL的潜在危险因素。>结果：总共有570名参与者被诊断为EPL。在未调整或调整后的模型中，我们观察到EPL与吸烟或饮酒之间没有关联。在调整后的模型中，与饮用自来水的人相比，饮用浅井水的人的OR（95％CI）为1.84（1.18-2.89）。比较口腔健康状况良好的受试者，口腔健康状况极差或极差的受试者的ESD / ESCC OR（95％CI）分别为1.78（1.28-2.49）和1.58（1.16-2.15）。但是，调整后没有观察到统计学意义。此外，谷物秸秆加热（OR = 1.74，95％CI：0.90-3.36，P = 0.099）可能导致EPL风险增加。>结论：在肥城市人口中，吸烟或饮酒未必是EPL的风险因素。劣质饮用水增加了EPL的风险。不良的房屋取暖材料，例如谷物秸秆，可能会导致高EPL风险。

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