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首页> 美国卫生研究院文献>Oxidative Medicine and Cellular Longevity >Defatted Kenaf (Hibiscus cannabinus L.) Seed Meal and Its Phenolic-Saponin-Rich Extract Protect Hypercholesterolemic Rats against Oxidative Stress and Systemic Inflammation via Transcriptional Modulation of Hepatic Antioxidant Genes
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Defatted Kenaf (Hibiscus cannabinus L.) Seed Meal and Its Phenolic-Saponin-Rich Extract Protect Hypercholesterolemic Rats against Oxidative Stress and Systemic Inflammation via Transcriptional Modulation of Hepatic Antioxidant Genes

机译：脱脂的红麻（Hibiscus cannabinus L.）籽粉及其富含酚皂甙的提取物通过转录调节肝脏抗氧化基因保护高胆固醇血症大鼠免受氧化应激和全身性炎症。

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The present study aimed to investigate the antioxidant and anti-inflammatory properties of defatted kenaf seed meal (DKSM) and its phenolic-saponin-rich extract (PSRE) in hypercholesterolemic rats. Hypercholesterolemia was induced using atherogenic diet feeding, and dietary interventions were conducted by incorporating DKSM (15% and 30%) or PSRE (at 2.3% and 4.6%, resp., equivalent to the total content of DKSM-phenolics and saponins in the DKSM groups) into the atherogenic diets. After ten weeks of intervention, serum total antioxidant capacities of hypercholesterolemic rats were significantly enhanced by DKSM and PSRE supplementation (p < 0.05). Similarly, DKSM and PSRE supplementation upregulated the hepatic mRNA expression of antioxidant genes (Nrf2, Sod1, Sod2, Gsr, and Gpx1) of hypercholesterolemic rats (p < 0.05), except for Gpx1 in the DKSM groups. The levels of circulating oxidized LDL and proinflammatory biomarkers were also markedly suppressed by DKSM and PSRE supplementation (p < 0.05). In aggregate, DKSM and PSRE attenuated the hypercholesterolemia-associated oxidative stress and systemic inflammation in rats, potentially by enhancement of hepatic endogenous antioxidant defense via activation of the Nrf2-ARE pathway, which may be contributed by the rich content of phenolics and saponins in DKSM and PSRE. Hence, DKSM and PSRE are prospective functional food ingredients for the potential mitigation of atherogenic risks in hypercholesterolemic individuals.
机译：本研究旨在研究高胆固醇血症大鼠中脱脂的洋麻籽粉（DKSM）及其富含酚皂甙的提取物（PSRE）的抗氧化和抗炎特性。高胆固醇血症是通过动脉粥样硬化饮食喂养引起的，饮食干预是通过掺入DKSM（15％和30％）或PSRE（分别为2.3％和4.6％）进行的，相当于DKSM中酚类和皂苷的总含量组）进入致动脉粥样化的饮食。干预十周后，补充DKSM和PSRE可以显着增强高胆固醇血症大鼠的血清总抗氧化能力（p <0.05）。类似地，除了DKSM组中的Gpx1外，补充DKSM和PSRE可以上调高胆固醇血症大鼠（p <0.05）的抗氧化剂基因（Nrf2，Sod1，Sod2，Gsr和Gpx1）的肝mRNA表达。补充DKSM和PSRE还可以显着抑制循环氧化LDL和促炎生物标志物的水平（p <0.05）。总体而言，DKSM和PSRE可能通过激活Nrf2-ARE途径增强肝脏内源性抗氧化剂防御，从而减轻了大鼠与高胆固醇血症相关的氧化应激和全身性炎症，这可能是由于DKSM中酚类和皂苷的含量丰富和PSRE。因此，DKSM和PSRE是潜在的功能性食品成分，可以减轻高胆固醇血症患者的致动脉粥样硬化风险。

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