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首页> 美国卫生研究院文献>Journal of Bacteriology >Regulation of Thymidine Metabolism in Escherichia coli K-12: Studies on the Inducer and the Coordinateness of Induction of the Enzymes
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Regulation of Thymidine Metabolism in Escherichia coli K-12: Studies on the Inducer and the Coordinateness of Induction of the Enzymes

机译：大肠杆菌K-12中胸苷代谢的调节：诱导剂和酶诱导的协调性的研究

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摘要

A study was made of the regulation of three enzymes that act sequentially in the metabolism of thymidine in Escherichia coli K-12. Under a variety of conditions, two of the enzymes, thymidine phosphorylase and deoxyribose-5-phosphate aldolase, were found to be synthesized coordinately. However, the third enzyme, phosphodeoxyribomutase, was synthesized noncoordinately with the other two enzymes under the same conditions. In addition, the mutase could be fully induced, whereas basal levels of the phosphorylase and the aldolase were maintained. These findings indicate that two operons comprise the genes concerned with the reversible pathway leading from thymidine to acetaldehyde and glyceraldehyde-3-phosphate. In addition to thymidine, it was found that acetaldehyde was an external inducer of these enzymes. The results of induction experiments performed on wild-type cells and mutants defective in the mutase or the aldolase, with thymidine or acetaldehyde as exogenous inducers, strongly suggest that deoxyribose-5-phosphate is more proximal to the intracellular inducer than is thymidine, deoxyribose-1-phosphate, or acetaldehyde.
机译：进行了对三种酶的调节的研究，所述三种酶在大肠杆菌K-12中的胸苷的代谢中顺序起作用。在多种条件下，发现两种酶可协同合成胸苷磷酸化酶和脱氧核糖-5-磷酸醛缩酶。但是，第三种酶，磷酸脱氧核糖核糖核酸酶，是在相同条件下与其他两种酶非配位合成的。另外，可以完全诱导突变酶，而维持磷酸化酶和醛缩酶的基础水平。这些发现表明，两个操纵子包含与从胸苷到乙醛和3-磷酸甘油醛的可逆途径有关的基因。除胸苷外，还发现乙醛是这些酶的外在诱因。对野生型细胞和在突变酶或醛缩酶中有缺陷的突变体（以胸腺嘧啶或乙醛为外源性诱导剂）进行的诱导实验结果强烈表明，脱氧核糖5-磷酸比胸苷，脱氧核糖-更靠近细胞内诱导剂。 1-磷酸或乙醛。

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