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An isobolographic analysis of the antinociceptive effect of xylopic acid in combination with morphine or diclofenac

机译:等剂量线法分析木二酸联合吗啡或双氯芬酸的镇痛作用

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摘要

Background:A common practice of managing pain globally is the combination of analgesics and this is aimed at facilitating patient compliance, simplifying prescription, and improving efficacy without increasing adverse effects. Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders and xylopic acid (XA) present in the fruit extract have been shown to possess analgesic properties in animals. There is the likelihood of concomitant use of XA and the commonly used analgesics in traditional settings. This study, therefore, evaluated the pharmacologic interaction between XA/morphine and xylopic/diclofenac combinations.
机译:背景:在全球范围内管理疼痛的一种常见做法是将止痛药联合使用,其目的是促进患者依从性,简化处方并提高疗效而又不增加副作用。 Xeopiaopia aethiopica的水果提取物传统上用于治疗疼痛,并且水果提取物中存在的草二酸(XA)已显示对动物具有镇痛作用。在传统环境中可能会同时使用XA和常用的止痛药。因此,这项研究评估了XA /吗啡与木二酚/双氯芬酸组合之间的药理相互作用。

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