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首页> 美国卫生研究院文献>Journal of Basic and Clinical Pharmacy >Thrombolytic potential of Ocimum sanctum L. Curcuma longa L. Azadirachta indica L. and Anacardium occidentale L.
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Thrombolytic potential of Ocimum sanctum L. Curcuma longa L. Azadirachta indica L. and Anacardium occidentale L.

机译：Ocimum sanctum L.Curcuma longa L.Azadirachta indica L. Anacardium occidentale L.的溶栓潜力。

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Atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formed xin blood vessels. Thrombolytic agents are used to dissolve the already formed clots in the blood vessels; however, these drugs have certain limitations which cause serious and sometimes fatal consequences. Herbal preparations have been used since ancient times for the treatment of several diseases. The aim of this study was to investigate whether herbal preparations possess thrombolytic activity or not. An in vitro thrombolytic model was used to check the clot lysis effect of four aqueous herbal extracts viz., O. sanctum, C. longa, A. indica, A. occidentale along with Streptokinase as a positive control and water as a negative control. The percentage (%) clot lysis was statistically significant (p<0.0001) when compared with vehicle control. Using an in vitro thrombolytic model, O. sanctum, C. longa, A. indica & A. occidentale showed moderate clot lysis activity (30.01 ± 6.168%, 32.94 ± 3.663%, 27.47 ± 6.943%, 33.79 ± 2.926% respectively) whereas standard streptokinase showed 86.2 ± 10.7 % clot lysis effect. From our study we found that all the herbs showed reasonable % of clot lysis. These herbal extracts possess thrombolytic properties that could lyse blood clots in vitro; however, in vivo clot dissolving properties and active component(s) of these extracts for clot lysis are yet to be discovered
机译：诸如心肌或脑梗塞之类的血栓栓塞性疾病是血栓形成的新血管的严重后果。溶栓剂用于溶解血管中已经形成的血凝块。但是，这些药物具有一定的局限性，会导致严重甚至致命的后果。从远古时代开始就使用草药制剂来治疗多种疾病。这项研究的目的是调查草药制剂是否具有溶栓活性。使用体外溶栓模型检查四种含水草药提取物的凝块溶解效果，即圣果，龙眼，印度A，西洋参，链球菌激酶作为阳性对照，水作为阴性对照。与溶媒对照相比，血块溶解百分比（％）具有统计学意义（p <0.0001）。使用体外溶栓模型，圣殿，长角,、印度A和西方A显示出中等的血块溶解活性（分别为30.01±6.168％，32.94±3.663％，27.47±6.943％，33.79±2.926％）标准链激酶显示出86.2±10.7％的血块溶解效果。通过我们的研究，我们发现所有草药均显示出合理的凝块溶解百分比。这些草药提取物具有溶栓特性，可以在体外溶解血凝块。然而，尚未发现这些提取物在体内的血凝块溶解特性和活性成分。

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