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首页> 美国卫生研究院文献>Journal of Animal Science and Biotechnology >Mining the key regulatory genes of chicken inosine 5′-monophosphate metabolism based on time series microarray data
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Mining the key regulatory genes of chicken inosine 5′-monophosphate metabolism based on time series microarray data

机译：基于时间序列芯片数据挖掘鸡肌苷5-单磷酸代谢关键调控基因

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IMP (inosine 5′-monophosphate) is a compound that enhances the flavor of poultry meat. IMP has become a new breeding trait to improve poultry meat quality. We tried to identify several potential regulatory genes, and construct their predicted regulatory relationships. Time series gene expression profiles of thigh muscle tissues of Rugao chicken, a famous indigenous breed in China, were performed for analysis of genes that are co-expressed or correlated with the concentration of IMP. We found 15 crucial co-expression genes, which are Hspa2, Pten, Gabpa, Bpi, Mkl1, Srf, Cd34, Hspa4, Etv6, Bmpr2, Gde1, Igfbp5, Cd28, Pecam1 and Gja1, that may directly or indirectly regulate IMP metabolism. Eventually, we computed the correlation coefficient between 19 IMP Genes and 15 CGs (15 co-expression genes), and we identified and constructed a predicted regulation network. In conclusion, variation of IMP concentration was primarily connected with the muscle development process. During this process, 15 CGs were identified that may have significant influence on IMP metabolism. In particular, Bmpr2, Pten and co-expression genes correlated with Entpd8 might play important roles in regulating IMP de novo synthesis, decomposition and salvage synthesis.Electronic supplementary materialThe online version of this article (doi:10.1186/s40104-015-0022-3) contains supplementary material, which is available to authorized users.
机译：IMP（肌苷5'-单磷酸酯）是增强禽肉风味的化合物。 IMP已成为提高家禽肉品质的新育种特性。我们试图确定几种潜在的调控基因，并构建其预测的调控关系。进行了中国著名土著品种如uga鸡大腿肌肉组织的时间序列基因表达谱分析，以分析与IMP浓度共表达或相关的基因。我们发现了15个关键的共表达基因，分别是Hspa2，Pten，Gabpa，Bpi，Mkl1，Srf，Cd34，Hspa4，Etv6，Bmpr2，Gde1，Igfbp5，Cd28，Pecam1和Gja1，它们可以直接或间接调节IMP代谢。最终，我们计算了19个IMP基因和15个CG（15个共表达基因）之间的相关系数，并确定并构建了预测的调控网络。总之，IMP浓度的变化主要与肌肉发育过程有关。在此过程中，确定了15种可能对IMP代谢产生重大影响的CG。特别是与Entpd8相关的Bmpr2，Pten和共表达基因可能在调节IMP从头合成，分解和挽救性合成中起重要作用。电子补充材料本文的在线版本（doi：10.1186 / s40104-015-0022-3 ）包含补充材料，授权用户可以使用。

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