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首页> 美国卫生研究院文献>Journal of the American Association for Laboratory Animal Science : JAALAS >Use of Fenbendazole-Containing Therapeutic Diets for Mice in Experimental Cancer Therapy Studies
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Use of Fenbendazole-Containing Therapeutic Diets for Mice in Experimental Cancer Therapy Studies

机译：芬苯达唑治疗性饮食在实验性癌症治疗研究中的用途。

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Pinworm infection (oxyuriasis) is a common problem in rodent colonies. Facility-wide prophylactic treatment of all mice with a diet containing therapeutic levels of fenbendazole for several weeks is often used to control pinworm outbreaks. We examined the effect of feeding a therapeutic diet containing 150 ppm fenbendazole on the growth of EMT6 mouse mammary tumors implanted into BALB/c Rw mice. Mice were randomized to receive either a fenbendazole-containing or control diet for 1 wk before tumor cells were injected intradermally in the flanks and throughout tumor growth. Tumor growth was monitored by serial measurements of tumor diameters from the time tumors became palpable until they reached 1000 mm3. The medicated diet did not alter tumor growth, invasion, or metastasis. When tumors reached volumes of approximately 100 mm3, some were irradiated locally with 10 Gy of X-rays. Irradiation significantly delayed tumor growth; fenbendazole did not alter the radiation-induced growth delay. However, cell culture studies showed that fenbendazole concentrations not far above those expected in the tissues of mice on this diet altered the growth of the tumor cells in culture. Recent data from other laboratories also have demonstrated effects of fenbendazole that could complicate experiments. Care should therefore be exercised in deciding whether chow containing fenbendazole should be administered to mouse colonies being used in cancer research.
机译：worm虫感染（尿酸症）是啮齿类动物群落中的常见问题。经常使用含有芬苯达唑治疗水平的饮食对所有小鼠进行全院范围的预​​防性治疗数周，通常用于控制pin虫的爆发。我们检查了饲喂含有150 ppm芬苯达唑的治疗饮食对植入BALB / c Rw小鼠的EMT6小鼠乳腺肿瘤生长的影响。在将肿瘤细胞皮内注射到侧腹以及整个肿瘤生长之前，将小鼠随机接受含芬苯达唑或对照饮食1周。从肿瘤可触知到达到1000 mm 3 为止，通过连续测量肿瘤直径来监测肿瘤的生长。含药饮食不会改变肿瘤的生长，侵袭或转移。当肿瘤的体积达到约100 mm 3 时，用10 Gy的X射线局部照射。辐射明显延迟了肿瘤的生长；芬苯达唑不改变辐射诱导的生长延迟。然而，细胞培养研究表明，使用该饮食的芬苯达唑浓度不超过小鼠组织中预期的浓度，这改变了培养物中肿瘤细胞的生长。其他实验室的最新数据也证明了芬苯达唑的作用可能使实验复杂化。因此，在决定是否应对用于癌症研究的小鼠菌落施用含芬苯达唑的食物时应格外小心。

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