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首页> 美国卫生研究院文献>Journal of Allergy >Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray
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Treatment of Allergic Rhinitis with Ectoine Containing Nasal Spray and Eye Drops in Comparison with Azelastine Containing Nasal Spray and Eye Drops or with Cromoglycic Acid Containing Nasal Spray

机译：与含氮司他汀鼻腔喷雾剂和滴眼剂或含cromoglycic acid鼻腔喷雾剂相比含鼻喷剂和依他汀的治疗过敏性鼻炎

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摘要

Objectives. Allergic rhinitis is a common disease with increasing prevalence and high impact on economic burden and comorbidities. As treatment with pharmacological drugs is not always satisfactory due to side effects and incomplete efficacy, alternative treatment strategies are needed. Ectoine is an osmolyte with membrane stabilizing and inflammation reducing capacities. Nasal spray and eye drops containing ectoine are promising new treatment regimens for allergic rhinitis sufferers. Design and Methods. The current two noninterventional trials evaluated the efficacy and safety of ectoine containing nasal spray and eye drops for treating allergic rhinitis in comparison with either azelastine or cromoglycic acid containing products. Nasal and ocular symptom developments as well as judgment of tolerability and efficacy were assessed both by investigators and patients over a time period of one to two weeks. Results. Both trials confirmed that ectoine containing products reduced nasal and ocular symptoms in allergic rhinitis patients. Results clearly demonstrated good safety profiles of the ectoine products comparable to those of azelastine and even better to those of cromoglycate products. Conclusion. Ectoine containing nasal spray and eye drops are interesting new treatment strategies for sufferers of allergic rhinitis, combining both good efficacy and absence of side effects.
机译：目标。变应性鼻炎是一种常见疾病，其患病率不断提高，对经济负担和合并症的影响很大。由于药物的副作用和不完全的疗效并不总是令人满意的，因此需要其他治疗策略。 Ectoine是一种渗透膜，具有稳定膜和减少炎症的能力。鼻腔喷雾剂和含植物胶的滴眼剂有望成为过敏性鼻炎患者的新疗法。设计和方法。当前的两项非干预性试验与含氮卓斯汀或色甘酸的产品相比，评估了含有ectoine的鼻喷剂和滴眼剂治疗过敏性鼻炎的有效性和安全性。研究者和患者在一到两周的时间内评估了鼻和眼症状的发展以及对耐受性和功效的判断。结果。两项试验均证实，含有变应原的产品可减轻过敏性鼻炎患者的鼻和眼症状。结果清楚地表明，与氮卓斯汀相比，外泌素产品具有良好的安全性，甚至与色甘膦酸酯产品相比具有更高的安全性。结论。对于过敏性鼻炎患者而言，含有鼻饲喷雾剂和滴眼液的电子烟酸是有趣的新治疗策略，兼具良好的疗效和无副作用。

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