• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Annual International Conference on Material Science and Environmental Engineering >A hypothesis of the Effect of a New Nasal Spray Made from Natural Medicines on Allergic Rhinitis in Animals
【24h】

A hypothesis of the Effect of a New Nasal Spray Made from Natural Medicines on Allergic Rhinitis in Animals

机译：一种新的鼻腔喷雾从天然药物对动物过敏性鼻炎作用的假设

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To verify the effect of a new nasal spray made from natural medicines on allergic rhinitis in animals. Methods: The main natural medicines contained in Acusine nasal spray plus essential traditional Chinese medicine contained in drugs for allergic rhinitis in Chinese market were used. By preparation process of extraction of traditional Chinese medicine such as steam distillation, ethanol extraction, a new nasal spray made from natural medicines was prepared. In the meantime, 24 B ALB/c mice and New Zealand white rabbits were used. Then, mice were randomly divided into four group; control group, beclomethasone dipropionate group, Acusine group and new spray group, 6 mice in each group. Moreover, the effect of the new nasal spray made on passive cutaneous anaphylaxis was conducted by detecting absorptions of Evan's blue (620nm) in the four groups. Allergic rhinitis models in 40 New Zealand white rabbits were established. Consequently, 40 allergic rhinitis models in rabbits were randomly divided into control group, Acusine group and new spray group, 10 rabbits in each group. The four groups were sprayed nasally with saline, Acusine spray and new spray respectively, three times/d, for 30 days. The nasal resistances in the four groups were measured with a rhinoresistometcr. Moreover, their nasal mucosa was taken for HE staining. Consequently, their pathological manifestations were observed. The results: Absorption of Evan's blue (620nm) of new spray group will be found significantly lower than Acusine group (P<0.05) and will have no significantly difference compared with beclomethasone dipropionate group(P>0.05). On the other hand, absorption of Evan's blue (620nm) of beclomethasone dipropionate group will be significantly lower than Acusine group (P<0.05). Moreover, The nasal resistances of new spray group will be significantly lower than Acusine group (P<0.05) and will have no significantly difference compared with beclomethasone dipropionate group (P>0.05). Moreover, the nasal resistances of beclomethasone dipropionate group will be significantly lower than Acusine group (P<0.05). While, the nasal mucosa of control group will be found typical as nasal mucosa of allergic rhinitis. However, the nasal mucosa of beclomethasone dipropionate group, Acusine group and new spray group will be better than control group. Of them, new spray group will be the best. The nasal mucosa of beclomethasone dipropionate group will show the manifestation of drug-induced rhinitis. The conclusion: The invented new spray will not only have a better treatment effect on allergic rhinitis, similar with beclomethasone dipropionate, than Acusine Nasal Spray but also will not leave side effect on nasal mucosa, compared with beclomethasone dipropionate. Thus, the new spray made from natural medicines can be further studied as a better prescription drug, rather than an OTC like Acusine Nasal Spray, to replace beclomethasone dipropionate nasal spray. However, further study that would be required to produce a more meaningful answer.
机译：验证新的鼻喷雾的自然药物对动物的过敏性鼻炎。方法：采用了在中国市场中过敏性鼻炎药物中含有的Acusine鼻腔喷雾加原产药中所含的主要天然药物。通过制备蒸汽蒸馏等中药提取，乙醇提取，制备了一种新的自然药物制成的新鼻喷雾。与此同时，使用24b alb / c小鼠和新西兰白色兔子。然后，小鼠随机分为四组;对照组，依赖于双丙酸二甲酸二倍体基团，Acusine组和新的喷雾组，每组6只小鼠。此外，通过在四组中检测Evan蓝（620nm）的吸收来进行对被动皮肤过敏性的新鼻喷雾的效果。建立了40个新西兰白兔的过敏性鼻炎模型。因此，兔子中的40种过敏性鼻炎模型被随机分为对照组，Acusine组和新的喷雾组，每组10只兔。将四组用盐水，含量喷雾喷雾，三次/天，30天。用鼻流素测量测量四组的鼻抗性。此外，他们的鼻粘膜是为了染色。因此，观察到他们的病理表现。结果：对新喷雾组的Evan蓝色（620nm）的吸收将被发现显着低于Acusine组（P <0.05），与BECLOMELSONO二丙酸二倍体基团（P> 0.05）相比不会显着差异。另一方面，Evan的Blue（620nm）的BeClomethasone双丙酸酯基团的吸收将显着低于Acusine组（P <0.05）。此外，新喷雾组的鼻抗性将显着低于Acusine组（P <0.05），与BeClomethasone二丙酸二倍体基团相比没有显着差异（P> 0.05）。此外，BECLOMETHASONE双丙酸酯基团的鼻抗性将明显低于ACUSINE组（P <0.05）。虽然，对照组的鼻粘膜将被发现典型为过敏性鼻炎的鼻粘膜。然而，Eclomethasone二丙酸二甲酸二丙酸酯基团，Acusine组和新喷雾组的鼻粘膜将比对照组更好。其中，新的喷雾组将是最好的。 Eclomethasone双丙酸酯基团的鼻粘膜将显示出药物诱导的鼻炎的表现。结论：本发明的新喷雾不仅对过敏性鼻炎具有更好的治疗效果，与Beflomethasone滴水异常相似，而不是Acusine鼻腔喷雾，而且与BeClomethasone二丙酸甲酸乙酯相比，不会对鼻粘膜留下副作用。因此，可以进一步研究由天然药物制成的新喷雾，作为更好的处方药，而不是ACUSINE鼻喷雾等OTC，以取代ECLOMELSONE双发态鼻喷雾。然而，进一步的研究将需要产生更有意义的答案。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号