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首页> 美国卫生研究院文献>Iranian Journal of Basic Medical Sciences >Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats
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Improvement in Memory and Brain Long-term Potentiation Deficits Due to Permanent Hypoperfusion/Ischemia by Grape Seed Extract in Rats

机译：葡萄籽提取物对大鼠永久性低灌注/缺血引起的记忆力和脑长期增强能力的改善

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>Objective(s): Cerebral hypoperfusion/ischemia (CHI) is a neurological disease where impaired hippocampus electrical activity and cognition caused by a serial pathophysiological events. This study aimed to evaluate the effects of chronic oral administration of grape seed extract (GSE) on passive avoidance memory and long-term potentiation (LTP) after permanent bilateral common carotid arteries occlusion (2CCAO) in male adult rats. >Materials and Methods: Thirty-two adult male Wistar rats were randomly divided into: 1) Sham+Veh, 2) Isch+Veh, 3) Sham+GSE, 4) Isch+GSE. In order to make 2CCAO as an animal model of CHI, carotid arteries were ligatured and then cut bilaterally. To evaluation of passive avoidance memory, step-down latency (STL) was measured and LTP was recorded from hippocampal dentate gyrus (DG) after high frequency stimulation (HFS) in all rats. >Results: We found that memory was significantly impaired in rats after CHI (P<0.001) concomitant with hippocampal LTP inhibition (P<0.05, P<0.01 for LTP1 and LTP48 respectively). GSE treatment significantly improved memory impairment and increased hippocampal LTP in rats with 2CCAO. >Conclusion: Our results in present study suggest that GSE exhibits therapeutic potential for short-and long-term memories as well as LTP in DG, which is most likely related at least in part to its antioxidative and free radical scavenging actions.
机译：>目标：脑灌注不足/缺血（CHI）是一种神经系统疾病，其中一系列病理生理事件导致海马电活动和认知受损。本研究旨在评估长期口服葡萄籽提取物（GSE）对成年雄性大鼠永久性双侧颈总颈总动脉闭塞（2CCAO）后的被动回避记忆和长期增强（LTP）的影响。 >材料与方法：将32只成年雄性Wistar大鼠随机分为：1）Sham + Veh，2）Isch + Veh，3）Sham + GSE，4）Isch + GSE。为了使2CCAO成为CHI的动物模型，将颈动脉结扎，然后双侧切开。为了评估被动回避记忆，在所有大鼠中测量了高频刺激（HFS）后海马齿状回（DG）的降压潜伏期（STL），并记录了LTP。 >结果：我们发现，CHI（P <0.001）伴有海马LTP抑制后，大鼠记忆力显着受损（LTP1和LTP48分别为P <0.05，P <0.01）。 GSE治疗可显着改善2CCAO大鼠的记忆障碍并增加海马LTP。 >结论：我们在本研究中的结果表明，GSE对DG的短期和长期记忆以及LTP具有治疗潜力，这很可能至少部分与其抗氧化和自由基有关清除动作。

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