Background. Although many reports concerning the use of endoscopic submucosal dissection (ESD) for esophageal cancer have been published, the feasibility of ESD in elderly patients has not been reported. Therefore, we evaluated the efficacy and safety of ESD for treating early esophageal cancer in elderly patients. Methods. A total of 62 cases (52 men, 10 women; mean age ± standard deviation, 66.5 ± 10.5 years) for which the first resection (first treatment) of esophageal cancer was performed by ESD were identified from 77 consecutive esophageal epithelial cancers in 67 patients treated at our institution from January 2005 to March 2011. Patient characteristics, clinical findings, and outcomes were retrospectively assessed for patients separated into older (aged 75 years and older) and younger (aged under 75 years) groups. Results. No significant differences in specimen size, procedure time, median length of the hospital stay (8 versus 9 days; P = 0.252) or procedure-associated complications (8% versus 27%; P = 0.264) were observed between the older (n = 13) and younger (n = 49) groups. Lesions were completely resected in 12 patients and 44 patients, in the younger and older groups, respectively, and the curative resection rate was 77% and 59%, respectively. There were no deaths attributable to procedure-associated complications. Conclusions. ESD is an effective treatment for early esophageal cancer and is well tolerated by elderly patients.
展开▼
机译：背景。尽管已经发表了许多关于将内镜黏膜下剥离术（ESD）用于食道癌的报道，但尚未报道ESD在老年患者中的可行性。因此，我们评估了ESD治疗老年患者早期食道癌的有效性和安全性。方法。从67例连续的77例食管上皮癌中鉴别出经ESD首次切除（首次治疗）食管癌的62例病例（男52例，女10例；平均年龄±标准差，66.5±10.5岁）。我们对2005年1月至2011年3月在我院接受治疗的患者进行了回顾性评估。对年龄较大（75岁及以上）和年轻（75岁以下）的患者进行了回顾性评估。结果。年龄较大者（n = 2）中，标本大小，手术时间，中位住院时间（8天与9天； P = 0.252）或与手术相关的并发症（8％对27％； P = 0.264）没有显着差异。 13岁及以下（n = 49）组。在年轻组和老年组中，分别有12例和44例患者完全切除了病灶，治愈率分别为77％和59％。没有因手术相关并发症而死亡。结论。 ESD是早期食道癌的有效治疗方法，对老年患者具有很好的耐受性。
展开▼
