• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>ISRN Endocrinology >Diagnostic Value of the Combined Measurement of Serum Hcy Serum Cys C and Urinary Microalbumin in Type 2 Diabetes Mellitus with Early Complicating Diabetic Nephropathy
【2h】

Diagnostic Value of the Combined Measurement of Serum Hcy Serum Cys C and Urinary Microalbumin in Type 2 Diabetes Mellitus with Early Complicating Diabetic Nephropathy

机译：血清Hcy血清Cys C和尿微量白蛋白联合测定对2型糖尿病合并早期糖尿病肾病的诊断价值

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diabetic nephropathy (DN) is a major cause of end-stage kidney disease, and therefore early diagnosis and intervention may help reverse renal damage. One hundred and sixty-eight patients with T2DM and 56 healthy volunteers (control group) were enrolled at Shandong University Qilu Hospital between April 2010 and October 2012. All subjects underwent blood sampling for sera homocysteine (Hcy) and cystatin C (Cys C) assays and a urine microalbumin test. The patients were divided into three groups according to the urine microalbumin excretion rate (UMAER): the simple DM group (SDM group, n = 51), the early-stage DN group (EDN group, n = 60), and the clinical DN and renal failure group (CDN group, n = 57). Correlation analysis was performed to examine the association between sera Hcy and Cys C levels with UMAER. Our findings showed that sera Hcy level, Cys C level, and UMAER increased significantly in the SDM group (P < 0.05, P < 0.01), the EDN group (P < 0.01), and the CDN group (P < 0.01) as compared with the control group. These three biochemical markers also increased significantly with DN progression (P < 0.01). Correlation analysis showed that sera Hcy and Cys C levels were positively correlated with UMAER (r = 0.702, P < 0.01; r = 0.873, P < 0.01). In conclusion, our results showed that sera Hcy and Cys C levels increased consistently with the development and progression of DN as indicated by UMAER. Sera Hcy and Cys C are sensitive biomarkers for the detection of early-stage DN and monitoring its progression.
机译：糖尿病肾病（DN）是终末期肾脏疾病的主要原因，因此早期诊断和干预可能有助于逆转肾脏损害。 2010年4月至2012年10月，在山东大学齐鲁医院收治了168例T2DM患者和56名健康志愿者（对照组）。所有受试者均接受了血液采样以进行同型半胱氨酸（Hcy）和半胱氨酸蛋白酶抑制剂C（Cys C）检测和尿液微量白蛋白测试。根据尿微量白蛋白排泄率（UMAER）将患者分为三组：简单DM组（SDM组，n = 51），早期DN组（EDN组，n = 60）和临床DN肾功能衰竭组（CDN组，n = 57）。进行相关分析，以检测血清Hcy和Cys C水平与UMAER之间的关系。我们的发现表明，与SDM组（P <0.05，P <0.01），EDN组（P <0.01）和CDN组（P <0.01）相比，血清Hcy，Cys C和UMAER显着增加。与对照组。这三种生化标记物也随着DN的进展而显着增加（P <0.01）。相关分析表明，血清Hcy和Cys C水平与UMAER正相关（r = 0.702，P <0.01； r ​​= 0.873，P <0.01）。总之，我们的结果表明，血清Ucy和Cys C水平随着DN的发生和发展而不断增加。血清Hcy和半胱氨酸C是检测早期DN并监测其进展的敏感生物标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号