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首页> 美国卫生研究院文献>Iranian Journal of Pharmaceutical Research : IJPR >Chemical Profile and Anti-inflammatory Activity of Total Flavonoids from Glycyrrhiza Uralensis Fisch
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Chemical Profile and Anti-inflammatory Activity of Total Flavonoids from Glycyrrhiza Uralensis Fisch

机译：甘草中总黄酮的化学成分和抗炎活性

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摘要

Glycyrrhiza uralensis Fisch. (G. uralensis) is one of the most widely used herbal medicines. This study was designed to enrich total flavonoids (TFF) from G. uralensis. The chemical profile of TFF was identified by HPLC and colorimetric assay. The TFF mainly contained liquiritin apioside, liquiritin, isoliquiritin apioside, liquiritigenin and isoliquiritigenin without glycyrrhizic acid. To study the anti-inflammatory activity of TFF, the DMB-induced ear vasodilatation assay and carrageenan-induced rat paw edema model have been utilized. Treatment with TFF showed significant anti-inflammatory activities in the two models. The two in-vivo edema assays demonstrated that the TFF possesses significant dose-dependent anti-inflammatory activity, similar to that of indomethacin at a dose of 500 mg/kg. In rat paws with carrageenan, treatment with TFF (500 and 250 mg/kg) markedly inhibited the expression of IL-1β and iNOS. TFF at all doses noticeably decreased levels of NO and MDA at the site of inflammation, while only i.g. TFF at a dose of 500 mg/kg significantly decreased TNF-α levels in the carrageenan-injected paws. In addition, an increase in SOD activity was induced by TFF at all doses. These results revealed that TFF exhibited significant anti-inflammatory activity in acute inflammatory models.
机译：甘草（G. uralensis）是使用最广泛的草药之一。本研究旨在富集甘草中的总黄酮（TFF）。通过HPLC和比色法鉴定TFF的化学特征。该TFF主要包含无甘草酸的liquiritin apioside，liquiritin，isoliquiritin apioside，liquiritigenin和isoliquiritigenin。为了研究TFF的抗炎活性，已经使用了DMB诱导的耳血管扩张测定法和角叉菜胶诱导的大鼠爪水肿模型。在两个模型中，TFF治疗显示出显着的抗炎活性。两种体内水肿试验表明，TFF具有明显的剂量依赖性抗炎活性，类似于消炎痛的剂量为500 mg / kg。在带有角叉菜胶的大鼠爪中，TFF（500和250 mg / kg）处理显着抑制IL-1β和iNOS的表达。所有剂量的TFF在炎症部位显着降低了NO和MDA的水平，而仅是例如。剂量为500 mg / kg的TFF可以显着降低角叉菜胶注射的爪中的TNF-α水平。另外，在所有剂量下，TFF诱导了SOD活性的增加。这些结果表明，TFF在急性炎症模型中表现出显着的抗炎活性。

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