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首页> 美国卫生研究院文献>Interdisciplinary Perspectives on Infectious Diseases >Enteroaggregative Escherichia coli: An Emerging Enteric Food Borne Pathogen
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Enteroaggregative Escherichia coli: An Emerging Enteric Food Borne Pathogen

机译：肠聚合性大肠杆菌：新兴的肠源性食品病原菌

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Enteroaggregative Escherichia coli (EAEC) are quite heterogeneous category of an emerging enteric pathogen associated with cases of acute or persistent diarrhea worldwide in children and adults, and over the past decade has received increasing attention as a cause of watery diarrhea, which is often persistent. EAEC infection is an important cause of diarrhea in outbreak and non-outbreak settings in developing and developed countries. Recently, EAEC has been implicated in the development of irritable bowel syndrome, but this remains to be confirmed. EAEC is defined as a diarrheal pathogen based on its characteristic aggregative adherence (AA) to HEp-2 cells in culture and its biofilm formation on the intestinal mucosa with a “stacked-brick” adherence phenotype, which is related to the presence of a 60 MDa plasmid (pAA). At the molecular level, strains demonstrating the aggregative phenotype are quite heterogeneous; several virulence factors are detected by polymerase chain reaction; however, none exhibited 100% specificity. Although several studies have identified specific virulence factor(s) unique to EAEC, the mechanism by which EAEC exerts its pathogenesis is, thus, far unknown. The present review updates the current knowledge on the epidemiology, chronic complications, detection, virulence factors, and treatment of EAEC, an emerging enteric food borne pathogen.
机译：肠聚合性大肠杆菌（EAEC）是与儿童和成人相关的急性或持续性腹泻病例相关的新兴肠病原体的异质性类别，在过去的十年中，由于水样腹泻而引起人们的关注日益增加，这种情况经常持续存在。 EAEC感染是发展中国家和发达国家爆发和非爆发环境中腹泻的重要原因。最近，EAEC已牵涉肠易激综合征的发展，但这仍有待确认。 EAEC被定义为腹泻病原体，是基于其对培养物中HEp-2细胞的特征性聚集粘附（AA）以及在肠粘膜上具有“堆积砖”粘附表型的生物膜形成，这与60的存在有关。 MDa质粒（pAA）。在分子水平上，表现出聚集表型的菌株是非常异质的。通过聚合酶链反应检测到几种毒力因子；但是，没有一个具有100％的特异性。尽管有几项研究已经确定了EAEC特有的特定毒力因子，但是EAEC发挥其发病机理的机制仍是未知的。本综述更新了有关流行病学，慢性并发症，检测，毒力因素和EAEC（一种新兴的肠道食源性病原体）的治疗的最新知识。

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