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首页> 美国卫生研究院文献>International Journal of Surgery Case Reports >Combination of bone marrow aspirate cancellous bone allograft and platelet-rich plasma as an alternative solution to critical-sized diaphyseal bone defect: A case series
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Combination of bone marrow aspirate cancellous bone allograft and platelet-rich plasma as an alternative solution to critical-sized diaphyseal bone defect: A case series

机译：骨髓穿刺同种异体骨移植和富含血小板的血浆的组合可替代临界尺寸的干dia端骨缺损：一个病例系列

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Introduction: Nonunion due to a critical-sized bone defect is a complicated problem. The healing process must fulfill three mandatory elements of osteogenesis, osteoinduction, and osteoconduction. One ideal source to provide an abundant number of osteogenic cells is from the process of the culture of bone marrow stem cells which demands the availability of processing facility. Unfortunately, this sophisticated option is not always feasible in every hospital in low-income to middle-income countries. We tried to fulfill the requirement of osteogenic cells by using simple and cost-effective bone marrow aspirate. We presented two cases of critical-sized diaphyseal bone defect treated with the combination of bone marrow aspirate, cancellous bone allograft, and platelet-rich plasma (PRP).Presentation of cases: The defect sizes were five and six centimeters in humerus and tibia respectively. We applied a combination of bone marrow aspirate, cancellous bone allograft, and PRP to promote bone healing in the defect sites. Both patients have achieved the good clinical and radiological outcome.Discussion: Critical-sized bone defects require the application of tissue engineering. Aspirated bone marrow can be used as a more affordable option to provide the element of osteogenic cells in bone healing. Combined with cancellous bone allograft and PRP, they fulfill the required ingredients to promote bone regeneration.Conclusion: Bone defects remain one of the most challenging conditions to treat in orthopedic. There are many options to treat the defect but the fundamental prerequisites of cells, scaffolds and growth factors for healing have developed into the concept of tissue engineering: osteogenesis, osteoinduction, and osteoconduction.
机译：简介：由于临界骨缺损而导致的骨不连是一个复杂的问题。愈合过程必须满足成骨，骨诱导和骨传导的三个强制性要素。提供大量成骨细胞的理想来源是来自骨髓干细胞的培养过程，这需要加工设备的可用性。不幸的是，这种复杂的选择并不总是适用于中低收入国家/地区的每家医院。我们试图通过使用简单且具有成本效益的骨髓穿刺液来满足成骨细胞的需求。我们介绍了2例临界尺寸的干phy端骨缺损，分别采用骨髓穿刺，同种异体骨移植和富血小板血浆（PRP）进行治疗。病例介绍：肱骨和胫骨缺损分别为5厘米和6厘米。我们应用了骨髓穿刺，同种异体骨移植和PRP的组合以促进缺损部位的骨愈合。两名患者均取得了良好的临床和放射学结果。讨论：严重的骨缺损需要组织工程学的应用。抽吸骨髓可以用作更实惠的选择，以提供骨愈合中成骨细胞的元素。结合同种异体骨同种异体骨和PRP，它们可满足促进骨再生的必需成分。结论：骨缺损仍然是整形外科治疗中最具挑战性的疾病之一。有许多治疗缺陷的选择，但是细胞，支架和生长因子愈合的基本前提条件已经发展成为组织工程学的概念：成骨，骨诱导和骨传导。

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