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首页> 外文期刊>Journal of orthopaedic research >In vivo study on the healing of bone defects treated with bone marrow stromal cells, platelet-rich plasma, and freeze-dried bone allografts, alone and in combination.
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In vivo study on the healing of bone defects treated with bone marrow stromal cells, platelet-rich plasma, and freeze-dried bone allografts, alone and in combination.

机译：单独或组合使用骨髓基质细胞，富含血小板的血浆和冻干的同种异体骨移植治疗骨缺损的体内研究。

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The repair of confined trabecular bone defects in rabbits treated by autologous bone marrow stromal cells (BMSC), platelet-rich plasma (PRP), freeze-dried bone allografts (FDBA) alone and in combination (BMSC + PRP; FDBA + BMSC; FDBA + PRP; FDBA + PRP + BMSC) was compared. A critical size defect was created in the distal part of the femurs of 48 adult rabbits. Histology and histomorphometry were used in the evaluation of healing at 2, 4, and 12 weeks after surgery. The healing rate (%) was calculated by measuring the residual bone defect area. Architecture of the newly formed bone was compared with that of bone at the same distal femur area of healthy rabbits. The defect healing rate was higher in PRP + BMSC, FDBA + PRP, FDBA + BMSC, and FDBA + PRP + BMSC treatments, while lower values were achieved with PRP treatment at all experimental times. The highest bone-healing rate at 2 weeks was achieved with FDBA + PRP + BMSC treatment, which resulted significantly different from PRP (p < 0.05) and BMSC (p < 0.05) treatments. At 4 weeks, the bone-healing rate increased except for PRP treatment. Finally, the bone-healing rate of FDBA + PRP, FDBA + BMSC, and FDBA + PRP + BMSC was significantly higher than that of PRP at 12 weeks (p < 0.05). At 12 weeks, significant differences still existed between PRP, BMSC, and FDBA groups and normal bone (p < 0.05). These results showed that the combination of FDBA, BMSC and PRP permitted an acceleration in bone healing and bone remodeling processes.
机译：自体骨髓基质细胞（BMSC），富血小板血浆（PRP），冻干同种异体骨移植（FDBA）单独和联合治疗（BMSC + PRP; FDBA + BMSC; FDBA）修复兔局限性小梁骨缺损+ PRP; FDBA + PRP + BMSC）。在48只成年兔子的股骨远端形成了一个临界大小缺陷。组织学和组织形态计量学用于评估术后2、4和12周的愈合情况。通过测量残余的骨缺损面积来计算治愈率（％）。比较了新形成的骨骼的结构和健康兔子同一股骨远端区域的骨骼的结构。 PRP + BMSC，FDBA + PRP，FDBA + BMSC和FDBA + PRP + BMSC处理的缺陷愈合率较高，而在所有实验时间使用PRP处理均达到较低的愈合率。 FDBA + PRP + BMSC治疗在2周时达到了最高的骨愈合率，这与PRP（p <0.05）和BMSC（p <0.05）治疗有显着差异。在4周时，除PRP治疗外，骨愈合率都有所提高。最后，在12周时，FDBA + PRP，FDBA + BMSC和FDBA + PRP + BMSC的骨愈合率显着高于PRP（p <0.05）。在第12周时，PRP，BMSC和FDBA组与正常骨骼之间仍然存在显着差异（p <0.05）。这些结果表明，FDBA，BMSC和PRP的组合可加速骨愈合和骨重塑过程。

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