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首页> 美国卫生研究院文献>International Journal of Reproductive Biomedicine >Beneficial effect of adding pentoxifylline to processed semen samples on ICSI outcome in infertile males with mild and moderate asthenozoospermia: A randomized controlled prospective crossover study
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Beneficial effect of adding pentoxifylline to processed semen samples on ICSI outcome in infertile males with mild and moderate asthenozoospermia: A randomized controlled prospective crossover study

机译：在已加工精液样本中添加己酮可可碱对轻度和中度弱精子症的不育男性ICSI结局的有益作用：一项随机对照前瞻性交叉研究

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>Background: No extensive studies were done that included the use of pentoxifylline or verify its effect on the outcome of ICSI in cases of mild and moderate asthenozoospermia. >Objective: The aim of this study was to evaluate the effect of pentoxifylline used in preparation of semen samples which doesn't need motility enhancement prior to ICSI. >Materials and Methods: The study was carried on 30 infertile patients where pentoxifylline was used for semen processing (group I), another 30 patients without pentoxifylline (group II) in addition to 60 infertile patients where crossing over of the semen sample was done further subdividing it into 2 subgroups in which the first half of the semen sample was incubated with pentoxifylline (group IIIA) and the second half of the sample without pentoxifylline (group IIIB). >Results: The numbers of oocytes injected, numbers of oocytes fertilized, fertilization rate, the total numbers of embryos, numbers of good embryos and the numbers of embryos transferred of group IIIA were found significantly higher than that of Group IIIB (p=0.00). The overall 6 month pregnancy rate of group I was significantly higher than that of group II (73.3% vs. 60% respectively, p=0.04). The abortion rate of (Group I) and that of (Group II) was found non – significantly different (20% vs. 27.8% respectively, p=0.53). >Conclusion: Pentoxifylline can be used as a useful compound for improving ICSI outcome in semen samples preparation prior to oocytes injection regardless of the state of sperm motility or the degree of asthenozoospermia. >Registration ID in Clinical Trials.gov:
机译：>背景：没有进行广泛的研究，包括使用己酮可可碱或验证其对轻度和中度弱精子症患者ICSI结果的影响。 >目的：该研究的目的是评估己酮可可碱在精液样品制备中的作用，该样品在ICSI之前不需要增强运动能力。 >材料和方法：该研究针对30名使用己酮可可碱进行精液处理的不育患者（I组），另外30名无己酮可可碱的患者（II组）以及60例交叉使用将精液样品进一步细分为2个亚组，其中精液样品的前半部分与己酮可可碱（IIIA组）一起孵育，而后半部分的样品未与己酮可可碱（IIIB组）一起孵育。 >结果：发现IIIA组的卵母细胞注射数量，受精卵子数量，受精率，胚胎总数，优良胚胎数和转移的胚胎数均显着高于IIIA组。 IIIB（p = 0.00）。 I组的总体6个月妊娠率显着高于II组（分别为73.3％和60％，p = 0.04）。发现（I组）和（II组）的流产率无显着差异（分别为20％和27.8％，p = 0.53）。 >结论：己酮可可碱可用于改善卵母细胞注射前精液样品制备中ICSI结果的有用化合物，而与精子活动状态或弱精子症程度无关。 > Clinical Trials.gov中的注册ID：

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