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首页> 外文期刊>Iranian Journal of Reproductive Medicine >BENEFICIAL EFFECT OF ADDING PENTOXIFYLLINE TO PROCESSED SEMEN SAMPLES ON ICSI OUTCOME IN INFERTILE MALES WITH MILD AND MODERATE ASTHENOZOOSPERMIA: A RANDOMIZED CONTROLLED PROSPECTIVE CROSSOVER STUDY
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BENEFICIAL EFFECT OF ADDING PENTOXIFYLLINE TO PROCESSED SEMEN SAMPLES ON ICSI OUTCOME IN INFERTILE MALES WITH MILD AND MODERATE ASTHENOZOOSPERMIA: A RANDOMIZED CONTROLLED PROSPECTIVE CROSSOVER STUDY

机译：加工的精液样品中加入戊氧茶碱对患有轻度和中度无精子症的不育男性的ICSI结局的有益影响：随机对照的预期交叉研究

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Background: No extensive studies were done that included the use of pentoxifylline or verify its effect on the outcome of ICSI in cases of mild and moderate asthenozoospermia.Objective: The aim of this study was to evaluate the effect of pentoxifylline used in preparation of semen samples which doesn't need motility enhancement prior to ICSI. Materials and Methods: The study was carried on 30 infertile patients where pentoxifylline was used for semen processing (group I), another 30 patients without pentoxifylline (group II) in addition to 60 infertile patients where crossing over of the semen sample was done further subdividing it into 2 subgroups in which the first half of the semen sample was incubated with pentoxifylline (group IIIA) and the second half of the sample without pentoxifylline (group IIIB).Results: The numbers of oocytes injected, numbers of oocytes fertilized, fertilization rate, the total numbers of embryos, numbers of good embryos and the numbers of embryos transferred of group IIIA were found significantly higher than that of Group IIIB (p=0.00). The overall 6 month pregnancy rate of group I was significantly higher than that of group II (73.3% vs. 60% respectively, p=0.04). The abortion rate of (Group I) and that of (Group II) was found non a€“ significantly different (20% vs. 27.8% respectively, p=0.53).Conclusion: Pentoxifylline can be used as a useful compound for improving ICSI outcome in semen samples preparation prior to oocytes injection regardless of the state of sperm motility or the degree of asthenozoospermia.
机译：背景：没有进行广泛的研究，包括使用己酮可可碱或验证其对轻度和中度弱精子症患者的ICSI结果的影响。在ICSI之前不需要增强动力。材料和方法：这项研究针对30名不育患者使用己酮可可碱进行精液处理（I组），另外30位无己酮可可碱的患者（II组）以及60名不育患者进行精液样本交换将其分为2个亚组，其中精液样品的前半部分与己酮可可碱一起孵育（IIIA组），而无己酮可可碱的后半部分样品（IIIB组）进行培养。结果：注射的卵母细胞数量，受精的卵母细胞数量，受精率，发现IIIA组的胚胎总数，好胚胎数和转移的胚胎数显着高于IIIB组（p = 0.00）。 I组的总体6个月妊娠率显着高于II组（分别为73.3％和60％，p = 0.04）。发现（I组）和（II组）的流产率没有显着差异（分别为20％和27.8％，p = 0.53）。结论：己酮可可碱可作为改善ICSI的有用化合物卵母细胞注射前精液样品制备的结果与精子活动状态或弱精子症程度无关。

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