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首页> 美国卫生研究院文献>International Journal of Physiology Pathophysiology and Pharmacology >Influence of cimetidine and bromocriptine on prolactin levels in rat fertility
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Influence of cimetidine and bromocriptine on prolactin levels in rat fertility

机译：西咪替丁和溴隐亭对大鼠生育力催乳素水平的影响

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The present study was designed to see the effects of parenterally administered drugs cimetidine and bromocriptine affecting serum prolactin upon the fertility of adult male albino rats. Ninety adult young male albino rats between the ages of 60 to 120 days were selected. The animals were divided into three groups. Cimetidine was administered in a dose of 200 mg/kg body weight to group B intramuscularly and in addition to cimetidine, bromocriptine in a dose of 2.5 mg/day intramuscularly was given to group C. Normal saline was administered intramuscularly to control group A. Plasma prolactin was measured by Enzyme Immunoassays. Spermatogonia, spermatocytes, and spermatids were studied under oil immersion. The final plasma prolactin level instead of being elevated was found slightly depressed though insignificant in case of group B while remained slightly elevated instead of being suppressed/depressed though insignificant in group C. In group B spermatogenesis was normal in almost all of the tubules but a few of them were seen lined with only Sertoli cells and all the other germ cells like spermatogonia, primary spermatocytes, spermatids early and late, and spermatozoa were absent indicating total atrophy with both Sertoli cells and Leydig cells hyperplasia. While in the moderately affected tubules different types of spermatogonia A/B or intermediate were seen near the basement membrane. In group C both normal and abnormal germinal epithelium was seen in same/different tubules but a few of them were seen lined with only Sertoli cells and all the other germ cells like spermatogonia, primary spermatocytes, spermatids early and late, and spermatozoa were absent. The process of spermatogenesis was variable and appeared to be normal in most but in some it was found to be suppressed. This study revealed that the toxic effect of the drugs contributes to the infertility. It has not shown to be mediated through hormones in present study for which further research work is needed using low dose and longer duration to see the role of prolactin in causing infertility.
机译：本研究旨在观察胃肠外给药的西咪替丁和溴隐亭对血清催乳素的影响对成年雄性白化病大鼠生育能力的影响。选择了年龄在60至120天之间的90只成年雄性白化病雄性大鼠。将动物分为三组。西咪替丁以200 mg / kg体重的剂量经肌肉注射至B组，除西咪替丁外，溴隐亭以2.5 mg / day的剂量经肌肉注射至C组。生理盐水经肌肉注射给予对照组A。催乳素通过酶免疫测定法测量。在浸油下研究了精原细胞，精细胞和精子。最终血浆催乳素水平没有升高，但在B组中微不足道，尽管微不足道；而在C组中则略有降低，但并未抑制/降低，尽管在C组中微不足道。在B组中，几乎所有肾小管的生精均正常，但他们中几乎没有人看到仅衬有Sertoli细胞，以及所有其他生殖细胞，如精原细胞，原代精母细胞，早期和晚期精子，以及精子缺失，表明Sertoli细胞和Leydig细胞增生性完全萎缩。在中度受影响的肾小管中，在基底膜附近发现了不同类型的精原细胞A / B或中间体。 C组在相同/不同的肾小管中均可见正常和异常的生发上皮，但少数仅衬有支持细胞和所有其他生殖细胞，如精原细胞，原代精子细胞，早期和晚期的精子和精子。精子发生的过程是可变的，在大多数情况下似乎是正常的，但是在某些情况下，它被抑制了。这项研究表明，药物的毒性作用助长了不孕症。在目前的研究中，尚未显示它是通过激素介导的，因此需要进一步的研究工作，即使用低剂量和更长的时间来观察催乳素在引起不育症中的作用。

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