• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine and Research >Influence of cimetidine and bromocriptine on weight of rats and its relation with fertility
【24h】

Influence of cimetidine and bromocriptine on weight of rats and its relation with fertility

机译：西咪替丁和溴隐亭对大鼠体重的影响及其与生育力的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study was designed to see the influence of parenterally administered drugs cimetidine and bromocriptine on the weight of adult male albino rats and its relation with fertility. Ninety adult young male albino rats between the ages of 60 to 120 days were selected. The animals were divided into three groups. Cimetidine was administered in a dose of 200 mg/kg body weight to group B intramuscularly and in addition to cimetidine, bromocriptine in a dose of 2.5 mg/day intramuscularly was given to group C. Normal saline was administered intramuscularly to control group A.?Spermatogonia, spermotocytes, and spermatids were studied under oil immersion.?The difference between the initial and final body weight of group B was found to be highly significant statistically (P < 0.001) within the same group and also the mean final body weight was regarded highly significant statistically (P < 0.005) when compared with group C but when compared with control it was found insignificant.?The difference between the initial and final body weights of?group Cwas not significant within the group but it was definitely highly significant statistically (P < 0.001) and (P < 0.005) when compared with control group A and group B respectively. The spermatogenesis was normal in almost all of the tubulesof group B?but a few of them were seen lined with only? Sertoli cells and all the other germ cells like spermatogonia, primary spermatocyes, spermatids early and late, and spermatozoa were absent indicating total atrophy with both Sertoli cells and Leydig cells hyperplasia. However, the seminiferous tubules of group C were showing disorganisation/ disruption or both at the level of basal compartment of germinal epithelium in small quadrants, a quarter, half or more than half of their tubules indicating partial atrophy. Both normal and abnormal germinal epithelium was seen in same/different tubules but a few of them were seen lined with only Sertoli cells and all the other germ cells like spermatogonia, primary spermatocytes, spermatids early and late, and spermatozoa were absent. On the basis of the results of present study we could not exclude the possibility that besides the known anti-androgenic effect of cimetidine, a possible interference of cimetidine on the histoarchitecture of the seminiferous epithelium, as well as? lack of other biochemical factors essential for spermatogenesis could be involved in the testicular changes/ alterations of both groups B and C.
机译：本研究旨在观察胃肠外给药西咪替丁和溴隐亭对成年雄性白化病大鼠体重的影响及其与生育力的关系。选择了年龄在60至120天之间的90只成年雄性白化病雄性大鼠。将动物分为三组。西咪替丁以200 mg / kg体重的剂量肌内注射到B组，除西咪替丁外，溴隐亭以2.5 mg / day的剂量肌内注射到C组。生理盐水肌肉注射到对照组A。在浸油的情况下研究了精原细胞，精子细胞和精子细胞。？在同一组内，B组的初始体重和最终体重之间的差异具有统计学意义（P <0.001），并且被认为是平均最终体重与C组相比在统计学上具有显着统计学意义（P <0.005），但与对照组相比却无统计学意义。与对照组A和B组相比分别为P <0.001）和（P <0.005）。 B组的几乎所有肾小管的精子发生都是正常的，但其中的少数仅被观察到内衬？缺乏支持细胞和所有其他生殖细胞，如精原细胞，原代精子细胞，早期和晚期的精子和精子，这表明Sertoli细胞和Leydig细胞增生性萎缩。然而，C组的生精小管在小象限中在生发上皮的基底隔室水平上显示出混乱/破裂或两者均显示出它们的小管的四分之一，一半或一半以上，表明部分萎缩。在相同/不同的小管中都可以看到正常和异常的生殖上皮，但其中只有少数是支持细胞和所有其他生殖细胞，如精原细胞，原代精子细胞，早期和晚期的精子和精子。根据目前的研究结果，我们不能排除西咪替丁除了已知的抗雄激素作用外，还有可能干扰西咪替丁对生精上皮组织结构的影响，以及吗？ B和C组的睾丸变化/改变可能涉及精子发生所必需的其他生化因子的缺乏。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号